Simulations of Membrane Tubulation by Lattices of Amphiphysin N-BAR Domains

Overview

Journal Structure

Publisher Cell Press

Specialties Biochemistry
Biotechnology
Cell Biology
Molecular Biology

Date 2009 Jun 16

PMID 19523905

Citations 70

Authors

Ying Yin

Anton Arkhipov

Klaus Schulten

Affiliations

Soon will be listed here.

Abstract

Membrane compartments of manifold shapes are found in cells, often sculpted by cellular proteins. In particular, proteins of the BAR domain superfamily participate in membrane-sculpting processes in vivo and reshape also in vitro low-curvature membrane liposomes into high-curvature tubes and vesicles. Here we show by means of computer simulations totaling over 1 millisecond, how lattices involving parallel rows of amphiphysin N-BAR domains sculpt flat membranes into tubes. A highly detailed, dynamic picture of the 100-microsecond formation of membrane tubes by lattices of N-BAR domains is obtained. Lattice types inducing a wide range of membrane curvatures, with radii approximately 15-100 nm, are explored. The results suggest that multiple lattice types are viable for efficient membrane bending.

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