» Articles » PMID: 19523223

Hypoglycemic Herbs and Their Action Mechanisms

Overview
Journal Chin Med
Publisher Biomed Central
Date 2009 Jun 16
PMID 19523223
Citations 42
Authors
Affiliations
Soon will be listed here.
Abstract

Conventional drugs treat diabetes by improving insulin sensitivity, increasing insulin production and/or decreasing the amount of glucose in blood. Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex or even paradoxical in some cases. This article reviews recent findings about some of the most popular hypoglycemic herbs, such as ginseng, bitter melon and Coptis chinensis. Several popular commercially available herbal preparations are also discussed, including ADHF (anti-diabetes herbal formulation), Jiangtangkeli, YGD (Yerbe Mate-Guarana-Damiana) and BN (Byakko-ka-ninjin-to). The efficacy of hypoglycemic herbs is achieved by increasing insulin secretion, enhancing glucose uptake by adipose and muscle tissues, inhibiting glucose absorption from intestine and inhibiting glucose production from heptocytes.

Citing Articles

Development of Syringaldehyde as an Agonist of the GLP-1 Receptor to Alleviate Diabetic Disorders in Animal Models.

Lee J, Li Y, Cheng J, Liu I, Cheng K Pharmaceuticals (Basel). 2024; 17(4).

PMID: 38675498 PMC: 11054907. DOI: 10.3390/ph17040538.


LC-MS/MS, GC-MS and molecular docking analysis for phytochemical fingerprint and bioactivity of Beta vulgaris L.

Ust O, Yalcin E, Cavusoglu K, Ozkan B Sci Rep. 2024; 14(1):7491.

PMID: 38553576 PMC: 10980731. DOI: 10.1038/s41598-024-58338-7.


Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid.

Elghobashy M, Gama R, Sulaiman R Diagnostics (Basel). 2023; 13(20).

PMID: 37892096 PMC: 10606153. DOI: 10.3390/diagnostics13203275.


The Effects of on Type 2 Diabetes Mellitus and Alzheimer's Disease.

Richter E, Geetha T, Burnett D, Broderick T, Babu J Int J Mol Sci. 2023; 24(5).

PMID: 36902074 PMC: 10002567. DOI: 10.3390/ijms24054643.


Upregulation of Antioxidative Gene Expression by Organic Extract Improves the Predisposing Biomarkers and Tissue Architectures in Streptozotocin-Induced Diabetic Models of Long Evans Rats.

Sharmen F, Rahman M, Ahmed A, Siddique T, Rafi M, Tangpong J Antioxidants (Basel). 2022; 11(12).

PMID: 36552606 PMC: 9774390. DOI: 10.3390/antiox11122398.


References
1.
Thompson K, Liboiron B, Sun Y, Bellman K, Setyawati I, Patrick B . Preparation and characterization of vanadyl complexes with bidentate maltol-type ligands; in vivo comparisons of anti-diabetic therapeutic potential. J Biol Inorg Chem. 2002; 8(1-2):66-74. DOI: 10.1007/s00775-002-0388-5. View

2.
Chen Q, Chan L, Li E . Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr. 2003; 133(4):1088-93. DOI: 10.1093/jn/133.4.1088. View

3.
Neustadt J, Pieczenik S . Medication-induced mitochondrial damage and disease. Mol Nutr Food Res. 2008; 52(7):780-8. DOI: 10.1002/mnfr.200700075. View

4.
Puri D . The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study. J Ethnopharmacol. 2001; 78(1):89-93. DOI: 10.1016/s0378-8741(01)00306-3. View

5.
Ng T, Yeung H . Hypoglycemic constituents of Panax ginseng. Gen Pharmacol. 1985; 16(6):549-52. DOI: 10.1016/0306-3623(85)90140-5. View