Role of Scintigraphy in Inflammatory Bowel Disease

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2009 Jun 13

PMID 19522018

Citations 7

Authors

Maria I Stathaki

Sophia I Koukouraki

Nikolaos S Karkavitsas

Ioannis E Koutroubakis

Affiliations

Soon will be listed here.

Abstract

The diagnosis of inflammatory bowel disease (IBD) depends on direct endoscopic visualization of the colonic and ileal mucosa and the histological study of the obtained samples. Radiological and scintigraphic methods are mainly used as an adjunct to endoscopy. In this review, we focus on the diagnostic potential of nuclear medicine procedures. The value of all radiotracers is described with special reference to those with greater experience and more satisfactory results. Tc-99m hexamethylpropylene amine oxime white blood cells remain a widely acceptable scintigraphic method for the diagnosis of IBD, as well as for the evaluation of disease extension and severity. Recently, pentavalent Tc-99m dimercaptosuccinic acid has been recommended as an accurate variant and a complementary technique to endoscopy for the follow-up and assessment of disease activity. Positron emission tomography alone or with computed tomography using fluorine-18 fluorodeoxyglucose appears to be a promising method of measuring inflammation in IBD patients.

Citing Articles

Bringing the Inflamed and Fibrotic Bowel into Focus: Imaging in Inflammatory Bowel Disease.

Adler J, Stidham R, Higgins P Gastroenterol Hepatol (N Y). 2023; 5(10):705-715.

PMID: 37967416 PMC: 2886363.

Microbiome profile and calprotectin levels as markers of risk of recurrent infection.

Vazquez-Cuesta S, Lozano Garcia N, Fernandez A, Olmedo M, Kestler M, Alcala L Front Cell Infect Microbiol. 2023; 13:1237500.

PMID: 37780848 PMC: 10534046. DOI: 10.3389/fcimb.2023.1237500.

Toward Molecular Imaging of Intestinal Pathology.

Le Fur M, Zhou I, Catalano O, Caravan P Inflamm Bowel Dis. 2020; 26(10):1470-1484.

PMID: 32793946 PMC: 7500524. DOI: 10.1093/ibd/izaa213.

Accuracy of 99mTc (V)-Dimercaptosuccinic Acid Scintigraphy and Fecal Calprotectin Compared with Colonoscopy in Localizing Active Lesions in Inflammatory Bowel Disease.

Basirat V, Azizi Z, Anbardan S, Taghizadeh Asl M, Farbod Y, Teimouri A Middle East J Dig Dis. 2016; 8(3):212-218.

PMID: 27698971 PMC: 5045674. DOI: 10.15171/mejdd.2016.23.

Small bowel imaging of inflammatory bowel disease.

Casciani E, De Vincentiis C, Gualdi G World J Radiol. 2015; 7(8):198-201.

PMID: 26339463 PMC: 4553251. DOI: 10.4329/wjr.v7.i8.198.

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