Towards Retinoid Therapy for Alzheimer's Disease

Overview

Journal Curr Alzheimer Res

Publisher Bentham Science Publishers

Specialty Neurology

Date 2009 Jun 13

PMID 19519313

Citations 33

Authors

K Shudo

H Fukasawa

M Nakagomi

N Yamagata

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

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