Cause-specific Mortality in a Population-based Study of Diabetes

Overview

Journal Am J Public Health

Specialty Public Health

Date 1991 Sep 1

PMID 1951827

Citations 94

Authors

S E Moss

R Klein

B E Klein

Affiliations

Soon will be listed here.

Abstract

Background: Mortality from vascular diseases has been reported to be high in diabetic persons.

Methods: To evaluate mortality from these and other specific causes, we examined cause-specific age-sex standardized mortality ratios in a geographically defined population of younger onset (diagnosed before age 30 and taking insulin, n = 1200) and older onset (diagnosed after age 30, n = 1772) diabetic persons followed for 8.5 years. Cause of death was determined from death certificates.

Results: In younger onset persons, age-sex standardized mortality ratios were significantly high (P less than .05) for all causes of death (7.5) as well as for diabetes (191), all heart disease (9.1), ischemic heart disease (10.1), other heart disease (6.3), nephritis and nephrosis (41.2), accidents (2.9), and all other causes (3.2). In older onset persons, age-sex standardized mortality ratios were significantly high for all causes of death (2.0) as well as for diabetes (16.8), all heart disease (2.3), ischemic heart disease (2.3), other heart disease (2.1), stroke (2.0), and pneumonia and influenza (1.7).

Conclusions: Diabetic persons experience very high mortality, especially from vascular diseases, compared to the general population.

Citing Articles

Efficacy and Safety of Long-term Ketogenic Diet Therapy in a Patient With Type 1 Diabetes.

Koutnik A, Klein S, Robinson A, Watso J JCEM Case Rep. 2024; 2(7):luae102.

PMID: 38989268 PMC: 11234288. DOI: 10.1210/jcemcr/luae102.

Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.

Watso J, Robinson A, Singar S, Cuba J, Koutnik A Am J Physiol Cell Physiol. 2024; 327(2):C446-C461.

PMID: 38912731 PMC: 11427101. DOI: 10.1152/ajpcell.00694.2023.

Contribution of CKD to mortality in middle-aged and elderly people with diabetes: the China Health and Retirement Longitudinal Study : CKD was a chronic stressor for diabetics.

Liao X, Shi K, Zhang Y, Huang X, Wang N, Zhang L Diabetol Metab Syndr. 2023; 15(1):122.

PMID: 37291588 PMC: 10249178. DOI: 10.1186/s13098-023-01083-0.

Analysis of Cause-of-Death Mortality in Children and Young Adults with Diabetes: A Nationwide 10-Year Follow-Up Cohort Study.

Choi I, Yeom S, Kim S, You J, Kim J, Kim M Children (Basel). 2023; 10(2).

PMID: 36832487 PMC: 9955437. DOI: 10.3390/children10020358.

Relationships Between the Cumulative Incidences of Long-term Complications in Type 1 Diabetes: The DCCT/EDIC Study.

Bebu I, Braffett B, de Boer I, Aiello L, Bantle J, Lorenzi G Diabetes Care. 2022; 46(2):361-368.

PMID: 36520643 PMC: 9887612. DOI: 10.2337/dc22-1744.

References

Kessler I . Cancer mortality among diabetics. J Natl Cancer Inst. 1970; 44(3):673-86. View

PELL S, DALONZO C . Factors associated with long-term survival of diabetics. JAMA. 1970; 214(10):1833-40. View

Kessler I . Mortality experience of diabetic patients. A twenty-six-year follow-up study. Am J Med. 1971; 51(6):715-24. DOI: 10.1016/0002-9343(71)90299-3. View

PALUMBO P, ELVEBACK L, Chu C, Connolly D, Kurland L . Diabetes mellitus: incidence, prevalence, survivorship, and causes of death in Rochester, Minnesota, 1945-1970. Diabetes. 1976; 25(7):566-73. DOI: 10.2337/diab.25.7.566. View

HERMAN J, MEDALIE J, Goldbourt U . Differences in cardiovascular morbidity and mortality between previously known and newly diagnosed adult diabetics. Diabetologia. 1977; 13(3):229-34. DOI: 10.1007/BF01219704. View

Krolewski A, Czyzyk A, Janeczko D, Kopczynski J . Mortality from cardiovascular diseases among diabetics. Diabetologia. 1977; 13(4):345-50. DOI: 10.1007/BF01223277. View

Kannel W, McGee D . Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care. 1979; 2(2):120-6. DOI: 10.2337/diacare.2.2.120. View

Heyden S, Heiss G, Bartel A, HAMES C . Sex differences in coronary mortality among diabetics in Evans County, Georgia. J Chronic Dis. 1980; 33(5):265-73. DOI: 10.1016/0021-9681(80)90021-1. View

Jarrett R, McCartney P, Keen H . The Bedford survey: ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics. Diabetologia. 1982; 22(2):79-84. DOI: 10.1007/BF00254833. View

10.

Fuller J, Elford J, Goldblatt P, Adelstein A . Diabetes mortality: new light on an underestimated public health problem. Diabetologia. 1983; 24(5):336-41. DOI: 10.1007/BF00251820. View

11.

Fuller J, Shipley M, Rose G, Jarrett R, Keen H . Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study. Br Med J (Clin Res Ed). 1983; 287(6396):867-70. PMC: 1549302. DOI: 10.1136/bmj.287.6396.867. View

12.

Barrett-Connor E, Wingard D . Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol. 1983; 118(4):489-96. DOI: 10.1093/oxfordjournals.aje.a113654. View

13.

Klein R, Klein B, Moss S, DeMets D, Kaufman I, Voss P . Prevalence of diabetes mellitus in southern Wisconsin. Am J Epidemiol. 1984; 119(1):54-61. DOI: 10.1093/oxfordjournals.aje.a113725. View

14.

Dorman J, LaPorte R, Kuller L, Cruickshanks K, Orchard T, Wagener D . The Pittsburgh insulin-dependent diabetes mellitus (IDDM) morbidity and mortality study. Mortality results. Diabetes. 1984; 33(3):271-6. DOI: 10.2337/diab.33.3.271. View

15.

Klein R, Klein B, Moss S, Davis M, DeMets D . The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol. 1984; 102(4):520-6. DOI: 10.1001/archopht.1984.01040030398010. View

16.

Klein R, Klein B, Moss S, Davis M, DeMets D . The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol. 1984; 102(4):527-32. DOI: 10.1001/archopht.1984.01040030405011. View

17.

Green A, Hougaard P . Epidemiological studies of diabetes mellitus in Denmark: 5. Mortality and causes of death among insulin-treated diabetic patients. Diabetologia. 1984; 26(3):190-4. DOI: 10.1007/BF00252405. View

18.

Reunanen A . Mortality in type 2 diabetes. Ann Clin Res. 1983; 15 Suppl 37:26-8. View

19.

BUTLER W, Ostrander Jr L, Carman W, LAMPHIEAR D . Mortality from coronary heart disease in the Tecumseh study. Long-term effect of diabetes mellitus, glucose tolerance and other risk factors. Am J Epidemiol. 1985; 121(4):541-7. DOI: 10.1093/oxfordjournals.aje.a114031. View

20.

Geiss L, Herman W, Teutsch S . Diabetes and renal mortality in the United States. Am J Public Health. 1985; 75(11):1325-6. PMC: 1646717. DOI: 10.2105/ajph.75.11.1325. View