Paraneoplastic Movement Disorders

Overview

Journal Curr Neurol Neurosci Rep

Specialty Neurology

Date 2009 Jun 12

PMID 19515280

Citations 8

Authors

Shyamal H Mehta

John C Morgan

Kapil D Sethi

Affiliations

Soon will be listed here.

Abstract

Neurologic paraneoplastic syndromes (NPSs) result from damage to the nervous system due to the remote effects of cancer not related to metastasis, infection, or metabolic derangements. NPSs are rare, affecting 1 in 10,000 patients with cancer. Pathogenesis is likely related to the immune mechanisms: normal neural tissue is mistakenly attacked due to the similarity in the onconeural antigens expressed by the tumor cells. Among the various "classic" and other NPSs, this review focuses on paraneoplastic movement disorders, including ataxia due to cerebellar degeneration, stiff-person syndrome, opsoclonus-myoclonus syndrome, chorea, parkinsonism, and tremor. The recently described syndrome of paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis is also included, given that these patients have complex movements such as stereotypies and dyskinesias in addition to psychiatric symptoms, altered sensorium, and other neurologic signs. Although variable, treatment and prognosis of NPSs rely heavily on treatment of the underlying malignancy and immunotherapy.

Citing Articles

Paraneoplastic movement disorder due to suspected metastatic Leiomyosarcoma of tongue: A case report.

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Review of Hereditary and Acquired Rare Choreas.

Martinez-Ramirez D, Walker R, Rodriguez-Violante M, Gatto E Tremor Other Hyperkinet Mov (N Y). 2020; 10:24.

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MSA Mimic? Rare Occurrence of Anti-Hu Autonomic Failure and Thymoma in a Patient with Parkinsonism: Case Report and Literature Review.

Ricigliano V, Fossati B, Saraceno L, Cavalli M, Bazzigaluppi E, Meola G Front Neurosci. 2018; 12:17.

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Unilateral predominance of abnormal movements: A characteristic feature of the pediatric anti-NMDA receptor encephalitis?.

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Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy.

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