Zyxin Emerges As a Key Player in the Mechanotransduction at Cell Adhesive Structures

Overview

Journal Commun Integr Biol

Specialty Biology

Date 2009 Jun 11

PMID 19513257

Citations 42

Authors

Hiroaki Hirata

Hitoshi Tatsumi

Masahiro Sokabe

Affiliations

Soon will be listed here.

Abstract

Actin stress fiber (SF), focal adhesion (FA) and adherens junction (AJ) are known structures whose formation and development are mechanical force-dependent. At these structures, actin is actively polymerized, which in turn contributes the development of these structures. Recently, we reported that actin polymerization at FAs is facilitated by mechanical forces, which was critically dependent on the force-induced recruitment of the LIM protein zyxin to FAs. Zyxin enhances actin polymerization with the aid of Ena/VASP proteins. Both zyxin and Ena/VASP proteins are localized not only to FAs but also to AJs and SFs, facilitating actin polymerization at these structures. We discuss here the possibility that zyxin is a common mechanotransducer element regulating actin polymerization at FAs, AJs and SFs.

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