A Critical Process Controlled by MalT and OmpR is Revealed Through Synthetic Lethality

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2009 Jun 9

PMID 19502392

Citations 4

Authors

Sylvia A Reimann

Alan J Wolfe

Affiliations

Soon will be listed here.

Abstract

The death of cells harboring defects in two distinct pathways implicates these pathways in the control of an essential process. Here we report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.

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Constitutive expression of the maltoporin LamB in the absence of OmpR damages the cell envelope.

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