Cellular Trafficking of Nicotinic Acetylcholine Receptors

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2009 Jun 6

PMID 19498414

Citations 18

Authors

Paul A St John

Affiliations

Soon will be listed here.

Abstract

Nicotinic acetylcholine receptors (nAChRs) play critical roles throughout the body. Precise regulation of the cellular location and availability of nAChRs on neurons and target cells is critical to their proper function. Dynamic, post-translational regulation of nAChRs, particularly control of their movements among the different compartments of cells, is an important aspect of that regulation. A combination of new information and new techniques has the study of nAChR trafficking poised for new breakthroughs.

Citing Articles

Nicotinic Receptors in Human Chromaffin Cells: Characterization, Functional and Physical Interactions between Subtypes and Regulation.

Jimenez-Pompa A, Albillos A Int J Mol Sci. 2024; 25(4).

PMID: 38396980 PMC: 10888968. DOI: 10.3390/ijms25042304.

Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7.

Meganathan K, Prakasam R, Baldridge D, Gontarz P, Zhang B, Urano F BMC Biol. 2021; 19(1):147.

PMID: 34320968 PMC: 8317352. DOI: 10.1186/s12915-021-01080-7.

The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2 and α3β4 Receptors.

Scholze P, Huck S Front Synaptic Neurosci. 2020; 12:607959.

PMID: 33343327 PMC: 7744819. DOI: 10.3389/fnsyn.2020.607959.

AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study.

Hong Y, Liang X, Gilhus N Sci Rep. 2020; 10(1):11230.

PMID: 32641696 PMC: 7343820. DOI: 10.1038/s41598-020-68185-x.

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking.

Rudell J, Borges L, Yarov-Yarovoy V, Ferns M Front Mol Neurosci. 2020; 13:48.

PMID: 32265653 PMC: 7105636. DOI: 10.3389/fnmol.2020.00048.

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