Intrathecal Humoral Responses Are Inversely Associated with the Frequency of Simian Immunodeficiency Virus Macrophage-tropic Variants in the Central Nervous System

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2009 Jun 5

PMID 19494009

Citations 6

Authors

Elena Ryzhova

Pyone Aye

Tom Harvey

Wei Cao

Andrew Lackner

Francisco Gonzalez-Scarano

Affiliations

Soon will be listed here.

Abstract

Sustained simian immunodeficiency virus (SIV) infection of the central nervous system (CNS) depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. The CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response, in general, to control M-tropic strains. We investigated the temporal course of the intrathecal fusion inhibitory activity against an M-tropic viral variant and found an inverse relationship between the magnitude of this neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

Citing Articles

Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.

Atkinson J, Bergmann C J Virol. 2017; 91(23).

PMID: 28931676 PMC: 5686739. DOI: 10.1128/JVI.01352-17.

Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.

Yen P, Mefford M, Hoxie J, Williams K, Desrosiers R, Gabuzda D Virology. 2014; 458-459:53-68.

PMID: 24928039 PMC: 4112485. DOI: 10.1016/j.virol.2014.03.024.

Progression from IgD+ IgM+ to isotype-switched B cells is site specific during coronavirus-induced encephalomyelitis.

Phares T, DiSano K, Stohlman S, Bergmann C J Virol. 2014; 88(16):8853-67.

PMID: 24872583 PMC: 4136247. DOI: 10.1128/JVI.00861-14.

Intrathecal humoral immunity to encephalitic RNA viruses.

Phares T, Stohlman S, Bergmann C Viruses. 2013; 5(2):732-52.

PMID: 23435240 PMC: 3640523. DOI: 10.3390/v5020732.

Multiple sclerosis typical clinical and MRI findings in a patient with HIV infection.

Gonzalez-Duarte A, Ramirez C, Pinales R, Sierra-Madero J J Neurovirol. 2011; 17(5):504-8.

PMID: 21965121 DOI: 10.1007/s13365-011-0054-1.

References

Mankowski J, Clements J, Zink M . Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an accelerated, consistent simian immunodeficiency virus macaque model. J Infect Dis. 2002; 186 Suppl 2:S199-208. DOI: 10.1086/344938. View

Babas T, Dewitt J, Mankowski J, Tarwater P, Clements J, Zink M . Progressive selection for neurovirulent genotypes in the brain of SIV-infected macaques. AIDS. 2006; 20(2):197-205. DOI: 10.1097/01.aids.0000198078.24584.21. View

Desrosiers R, Ringler D . Use of simian immunodeficiency viruses for AIDS research. Intervirology. 1989; 30(6):301-12. DOI: 10.1159/000150108. View

Orandle M, Williams K, MacLean A, Westmoreland S, Lackner A . Macaques with rapid disease progression and simian immunodeficiency virus encephalitis have a unique cytokine profile in peripheral lymphoid tissues. J Virol. 2001; 75(9):4448-52. PMC: 114195. DOI: 10.1128/JVI.75.9.4448-4452.2001. View

Elovaara I, Seppala I, Poutiainen E, Suni J, Valle S . Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immunodeficiency virus infection. Neurology. 1988; 38(9):1451-6. DOI: 10.1212/wnl.38.9.1451. View

Clements J, Babas T, Mankowski J, Suryanarayana K, Piatak Jr M, Tarwater P . The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J Infect Dis. 2002; 186(7):905-13. DOI: 10.1086/343768. View

van Marle G, Rourke S, Zhang K, Silva C, Ethier J, Gill M . HIV dementia patients exhibit reduced viral neutralization and increased envelope sequence diversity in blood and brain. AIDS. 2002; 16(14):1905-14. DOI: 10.1097/00002030-200209270-00007. View

Chakrabarti L, Hurtrel M, Maire M, Vazeux R, Dormont D, Montagnier L . Early viral replication in the brain of SIV-infected rhesus monkeys. Am J Pathol. 1991; 139(6):1273-80. PMC: 1886455. View

Lane T, Buchmeier M, Watry D, Jakubowski D, Fox H . Serial passage of microglial SIV results in selection of homogeneous env quasispecies in the brain. Virology. 1995; 212(2):458-65. DOI: 10.1006/viro.1995.1503. View

10.

Ringler D, Hunt R, Desrosiers R, Daniel M, Chalifoux L, King N . Simian immunodeficiency virus-induced meningoencephalitis: natural history and retrospective study. Ann Neurol. 1988; 23 Suppl:S101-7. DOI: 10.1002/ana.410230726. View

11.

Puffer B, Pohlmann S, Edinger A, Carlin D, Sanchez M, Reitter J . CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity. J Virol. 2002; 76(6):2595-605. PMC: 135960. DOI: 10.1128/jvi.76.6.2595-2605.2002. View

12.

Dykhuizen M, Mitchen J, Montefiori D, Thomson J, ACKER L, Lardy H . Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression. J Gen Virol. 1998; 79 ( Pt 10):2461-7. DOI: 10.1099/0022-1317-79-10-2461. View

13.

Kim S, You X, Harmon M, Overbaugh J, Fan H . Use of helper-free replication-defective simian immunodeficiency virus-based vectors to study macrophage and T tropism: evidence for distinct levels of restriction in primary macrophages and a T-cell line. J Virol. 2001; 75(5):2288-300. PMC: 114812. DOI: 10.1128/JVI.75.5.2288-2300.2001. View

14.

Mori K, Ringler D, Kodama T, Desrosiers R . Complex determinants of macrophage tropism in env of simian immunodeficiency virus. J Virol. 1992; 66(4):2067-75. PMC: 288997. DOI: 10.1128/JVI.66.4.2067-2075.1992. View

15.

Williams K, Hickey W . Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu Rev Neurosci. 2002; 25:537-62. DOI: 10.1146/annurev.neuro.25.112701.142822. View

16.

Barber S, Gama L, Dudaronek J, Voelker T, Tarwater P, Clements J . Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model. J Infect Dis. 2006; 193(7):963-70. DOI: 10.1086/500983. View

17.

Zhang Z, Casimiro D, Schleif W, Chen M, Citron M, Davies M . Early depletion of proliferating B cells of germinal center in rapidly progressive simian immunodeficiency virus infection. Virology. 2007; 361(2):455-64. DOI: 10.1016/j.virol.2006.12.006. View

18.

Thomas E, Dunfee R, Stanton J, Bogdan D, Taylor J, Kunstman K . Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion. Virology. 2006; 360(1):105-19. PMC: 1890014. DOI: 10.1016/j.virol.2006.09.036. View

19.

Weber T, BUTTNER W, FELGENHAUER K . Evidence for different immune responses to HIV in CSF and serum?. Klin Wochenschr. 1987; 65(6):259-63. DOI: 10.1007/BF01773445. View

20.

Desrosiers R, Mori K, Bouvier D, King N, Daniel M, Ringler D . Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS. Am J Pathol. 1991; 139(1):29-35. PMC: 1886139. View