The Value of Animal Models in Predicting Genetic Susceptibility to Complex Diseases Such As Rheumatoid Arthritis

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2009 Jun 4

PMID 19490601

Citations 10

Authors

Emma Ahlqvist

Malin Hultqvist

Rikard Holmdahl

Affiliations

Soon will be listed here.

Abstract

For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.

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References

Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R . Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2002; 33(1):25-32. DOI: 10.1038/ng1058. View

Stastny P . Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest. 1976; 57(5):1148-57. PMC: 436767. DOI: 10.1172/JCI108382. View

Yoshitomi H, Sakaguchi N, Kobayashi K, Brown G, Tagami T, Sakihama T . A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med. 2005; 201(6):949-60. PMC: 2213107. DOI: 10.1084/jem.20041758. View

Nandakumar K, Svensson L, Holmdahl R . Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol. 2003; 163(5):1827-37. PMC: 1892447. DOI: 10.1016/S0002-9440(10)63542-0. View

Ahlqvist E, Bockermann R, Holmdahl R . Fragmentation of two quantitative trait loci controlling collagen-induced arthritis reveals a new set of interacting subloci. J Immunol. 2007; 178(5):3084-90. DOI: 10.4049/jimmunol.178.5.3084. View

Jirholt J, Lindqvist A, Holmdahl R . The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes. Arthritis Res. 2001; 3(2):87-97. PMC: 128884. DOI: 10.1186/ar145. View

Hitzemann B, Dains K, Kanes S, Hitzemann R . Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy. J Pharmacol Exp Ther. 1994; 271(2):969-76. View

Huang C, Zhan L, Hannigan M, Ai Y, Leto T . P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J Leukoc Biol. 2000; 67(2):210-5. DOI: 10.1002/jlb.67.2.210. View

Suntharalingam G, Perry M, Ward S, Brett S, Castello-Cortes A, Brunner M . Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006; 355(10):1018-28. DOI: 10.1056/NEJMoa063842. View

10.

Niki Y, Yamada H, Seki S, Kikuchi T, Takaishi H, Toyama Y . Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice. J Clin Invest. 2001; 107(9):1127-35. PMC: 209277. DOI: 10.1172/JCI11530. View

11.

Cook A, Rowley M, Stockman A, Muirden K, Mackay I . Specificity of antibodies to type II collagen in early rheumatoid arthritis. J Rheumatol. 1994; 21(7):1186-91. View

12.

Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H . Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum. 1986; 29(3):400-10. DOI: 10.1002/art.1780290314. View

13.

Botstein D, White R, Skolnick M, Davis R . Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980; 32(3):314-31. PMC: 1686077. View

14.

Swaak A, van Rooyen A, PLANTEN O, Han H, Hattink O, Hack E . An analysis of the levels of complement components in the synovial fluid in rheumatic diseases. Clin Rheumatol. 1987; 6(3):350-7. DOI: 10.1007/BF02206833. View

15.

Nandakumar K, Backlund J, Vestberg M, Holmdahl R . Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther. 2004; 6(6):R544-50. PMC: 1064861. DOI: 10.1186/ar1217. View

16.

Carlsen S, Hansson A, Olsson H, Heinegard D, Holmdahl R . Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats. Clin Exp Immunol. 1998; 114(3):477-84. PMC: 1905143. DOI: 10.1046/j.1365-2249.1998.00739.x. View

17.

Bauer K, Yu X, Wernhoff P, Koczan D, Thiesen H, Ibrahim S . Identification of new quantitative trait loci in mice with collagen-induced arthritis. Arthritis Rheum. 2004; 50(11):3721-8. DOI: 10.1002/art.20624. View

18.

Plenge R, Seielstad M, Padyukov L, Lee A, Remmers E, Ding B . TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med. 2007; 357(12):1199-209. PMC: 2636867. DOI: 10.1056/NEJMoa073491. View

19.

Glant T, Mikecz K, Arzoumanian A, Poole A . Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum. 1987; 30(2):201-12. DOI: 10.1002/art.1780300211. View

20.

Churchill G, Airey D, Allayee H, Angel J, Attie A, Beatty J . The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004; 36(11):1133-7. DOI: 10.1038/ng1104-1133. View