An FMRI Investigation of the Impact of Withdrawal on Regional Brain Activity During Nicotine Anticipation

Overview

Journal Psychophysiology

Specialty Psychiatry

Date 2009 Jun 4

PMID 19490513

Citations 32

Authors

Rebecca Gloria

Lisa Angelos

Hillary S Schaefer

James M Davis

Matthew Majeskie

Burke S Richmond

John J Curtin

Richard J Davidson

Timothy B Baker

Affiliations

Soon will be listed here.

Abstract

Previous research indicates that drug motivational systems are instantiated in structures that process information related to incentive, motivational drive, memorial, motor/habit, craving, and cognitive control processing. The present research tests the hypothesis that activity in such systems will be powerfully affected by the combination of drug anticipation and drug withdrawal. Event-related fMRI was used to examine activation in response to a preinfusion warning cue in two experimental sessions that manipulated withdrawal status. Significant cue-induced effects were seen in the caudate, ventral anterior nucleus of the thalamus, the insula, subcallosal gyrus, nucleus accumbens, and anterior cingulate. These results suggest that withdrawal and nicotine anticipation produce (1) different motor preparatory and inhibitory response processing and (2) different craving related processing.

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