Prokaryotic Ubiquitin-like Protein (Pup), Proteasomes and Pathogenesis

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2009 Jun 2

PMID 19483713

Citations 48

Authors

K Heran Darwin

Affiliations

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Abstract

Proteasomes are ATP-dependent, multisubunit proteases that are found in all eukaryotes and archaea and some bacteria. In eukaryotes, the small protein ubiquitin is covalently attached in a post-translational manner to proteins that are targeted for proteasomal degradation. Despite the presence of proteasomes in many prokaryotes, ubiquitin or other post-translational protein modifiers were presumed to be absent from these organisms. Recently a prokaryotic ubiquitin-like protein, Pup, was found to target proteins for proteolysis by the Mycobacterium tuberculosis proteasome. The discovery of this ubiquitin-like modifier opens up the possibility that other bacteria may also have small post-translational protein tagging systems, with the ability to affect cellular processes.

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