Development of Pharmacotherapies for Drug Addiction: a Rosetta Stone Approach

Overview

Journal Nat Rev Drug Discov

Specialty Pharmacology

Date 2009 Jun 2

PMID 19483710

Citations 67

Authors

George F Koob

G Kenneth Lloyd

Barbara J Mason

Affiliations

Soon will be listed here.

Abstract

Current pharmacotherapies for addiction represent opportunities for facilitating treatment and are forming a foundation for evaluating new medications. Furthermore, validated animal models of addiction and a surge in understanding of neurocircuitry and neuropharmacological mechanisms involved in the development and maintenance of addiction - such as the neuroadaptive changes that account for the transition to dependence and the vulnerability to relapse - have provided numerous potential therapeutic targets. Here, we emphasize a 'Rosetta Stone approach', whereby existing pharmacotherapies for addiction are used to validate and improve animal and human laboratory models to identify viable new treatment candidates. This approach will promote translational research and provide a heuristic framework for developing efficient and effective pharmacotherapies for addiction.

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References

Melis M, Spiga S, Diana M . The dopamine hypothesis of drug addiction: hypodopaminergic state. Int Rev Neurobiol. 2005; 63:101-54. DOI: 10.1016/S0074-7742(05)63005-X. View

Mucha R, Herz A . Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl). 1985; 86(3):274-80. DOI: 10.1007/BF00432213. View

Merlo Pich E, Lorang M, Yeganeh M, Rodriguez de Fonseca F, Raber J, Koob G . Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci. 1995; 15(8):5439-47. PMC: 6577636. View

Li Y, Vartanian A, White F, Xue C, Wolf M . Effects of the AMPA receptor antagonist NBQX on the development and expression of behavioral sensitization to cocaine and amphetamine. Psychopharmacology (Berl). 1998; 134(3):266-76. DOI: 10.1007/s002130050449. View

. Annual smoking-attributable mortality, years of potential life lost, and productivity losses--United States, 1997-2001. MMWR Morb Mortal Wkly Rep. 2005; 54(25):625-8. View

DOLE V . Implications of methadone maintenance for theories of narcotic addiction. JAMA. 1988; 260(20):3025-9. View

Koob G, Kreek M . Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007; 164(8):1149-59. PMC: 2837343. DOI: 10.1176/appi.ajp.2007.05030503. View

Tzschentke T . Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol. 1999; 56(6):613-72. DOI: 10.1016/s0301-0082(98)00060-4. View

Spangler R, Unterwald E, Kreek M . 'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Brain Res Mol Brain Res. 1993; 19(4):323-7. DOI: 10.1016/0169-328x(93)90133-a. View

10.

Wrase J, Schlagenhauf F, Kienast T, Wustenberg T, Bermpohl F, Kahnt T . Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage. 2007; 35(2):787-94. DOI: 10.1016/j.neuroimage.2006.11.043. View

11.

Tornatzky W, Miczek K . Cocaine self-administration "binges": transition from behavioral and autonomic regulation toward homeostatic dysregulation in rats. Psychopharmacology (Berl). 2001; 148(3):289-98. DOI: 10.1007/s002130050053. View

12.

Sills G . The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol. 2005; 6(1):108-13. DOI: 10.1016/j.coph.2005.11.003. View

13.

Weiss F, Koob G . Drug addiction: functional neurotoxicity of the brain reward systems. Neurotox Res. 2004; 3(1):145-56. DOI: 10.1007/BF03033235. View

14.

Weiss F, Markou A, Lorang M, Koob G . Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain Res. 1992; 593(2):314-8. DOI: 10.1016/0006-8993(92)91327-b. View

15.

Stringer S, Rueve M, Mossman D . Topiramate as treatment for alcohol dependence. JAMA. 2008; 299(4):405-6. DOI: 10.1001/jama.299.4.405-c. View

16.

Negus S, Henriksen S, Mattox A, Pasternak G, Portoghese P, TAKEMORI A . Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats. J Pharmacol Exp Ther. 1993; 265(3):1245-52. View

17.

Backstrom P, Hyytia P . Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology. 2005; 31(4):778-86. DOI: 10.1038/sj.npp.1300845. View

18.

Svensson K, Ekman A, Piercey M, Hoffmann W, Lum J, Carlsson A . Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors. A behavioral, biochemical and electrophysiological study. Naunyn Schmiedebergs Arch Pharmacol. 1991; 344(3):263-74. DOI: 10.1007/BF00182999. View

19.

Gabriel K, Cunningham C . Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Alcohol Clin Exp Res. 2005; 29(1):75-80. DOI: 10.1097/01.alc.0000150014.79657.64. View

20.

Childress A, Ehrman R, McLellan A, Macrae J, Natale M, OBrien C . Can induced moods trigger drug-related responses in opiate abuse patients?. J Subst Abuse Treat. 1994; 11(1):17-23. DOI: 10.1016/0740-5472(94)90060-4. View