Vibrational Spectroscopy: a Clinical Tool for Cancer Diagnostics

Overview

Journal Analyst

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2009 May 29

PMID 19475128

Citations 52

Authors

Catherine Kendall

Martin Isabelle

Florian Bazant-Hegemark

Joanne Hutchings

Linda Orr

Jaspreet Babrah

Rebecca Baker

Nicholas Stone

Affiliations

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Abstract

Vibrational spectroscopy techniques have demonstrated potential to provide non-destructive, rapid, clinically relevant diagnostic information. Early detection is the most important factor in the prevention of cancer. Raman and infrared spectroscopy enable the biochemical signatures from biological tissues to be extracted and analysed. In conjunction with advanced chemometrics such measurements can contribute to the diagnostic assessment of biological material. This paper also illustrates the complementary advantage of using Raman and FTIR spectroscopy technologies together. Clinical requirements are increasingly met by technological developments which show promise to become a clinical reality. This review summarises recent advances in vibrational spectroscopy and their impact on the diagnosis of cancer.

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