Use of Adipose Stem Cells and Polylactide Discs for Tissue Engineering of the Temporomandibular Joint Disc

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2009 May 29

PMID 19474082

Citations 17

Authors

Katja Maenpaa

Ville Ella

Jari Mauno

Minna Kellomaki

Riitta Suuronen

Timo Ylikomi

Susanna Miettinen

Affiliations

Soon will be listed here.

Abstract

There is currently no suitable replacement for damaged temporomandibular joint (TMJ) discs after discectomy. In the present study, we fabricated bilayer biodegradable polylactide (PLA) discs comprising a non-woven mat of poly(L/D)lactide (P(L/D)LA) 96/4 and a P(L/DL)LA 70/30 membrane plate. The PLA disc was examined in combination with adipose stem cells (ASCs) for tissue engineering of the fibrocartilaginous TMJ disc in vitro. ASCs were cultured in parallel in control and chondrogenic medium for a maximum of six weeks. Relative expression of the genes, aggrecan, type I collagen and type II collagen present in the TMJ disc extracellular matrix increased in the ASC-seeded PLA discs in the chondrogenic medium. The hypertrophic marker, type X collagen, was moderately induced. Alcian blue staining showed accumulation of sulphated glycosaminoglycans. ASC differentiation in the PLA discs was close to that observed in pellet cultures. Comparison of the mRNA levels revealed that the degree of ASC differentiation was lower than that in TMJ disc-derived cells and tissue. The pellet format supported the phenotype of the TMJ disc-derived cells under chondrogenic conditions and also enhanced their hyalinization potential, which is considered part of the TMJ disc degeneration process. Accordingly, the combination of ASCs and PLA discs has potential for the development of a tissue-engineered TMJ disc replacement.

Citing Articles

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Mesenchymal stem cells in craniofacial reconstruction: a comprehensive review.

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State of the Art in Temporomandibular Joint Arthrocentesis-A Systematic Review.

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940 nm diode laser induced differentiation of human adipose derived stem cells to temporomandibular joint disc cells.

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