Memory Deficits Are Associated with Impaired Ability to Modulate Neuronal Excitability in Middle-aged Mice

Overview

Journal Learn Mem

Specialty Neurology

Date 2009 May 28

PMID 19470651

Citations 69

Authors

Catherine C Kaczorowski

John F Disterhoft

Affiliations

Soon will be listed here.

Abstract

Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits were exposed in a subset (30%) of middle-aged mice that performed below criterion on a hippocampal-dependent contextual fear conditioning task. Basal neuronal excitability was comparable in middle-aged and young mice, but learning-related modulation of the post-burst afterhyperpolarization (AHP)--a general mechanism engaged during learning--was impaired in CA1 neurons from middle-aged weak learners. Thus, modulation of neuronal excitability is critical for retention of context fear in middle-aged mice. Disruption of AHP plasticity may contribute to contextual fear deficits in middle-aged mice--a model of age-associated cognitive decline (AACD).

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