Liver Architecture, Cell Function, and Disease

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2009 May 27

PMID 19468732

Citations 64

Authors

Hiromi Ishibashi

Minoru Nakamura

Atsumasa Komori

Kiyoshi Migita

Shinji Shimoda

Affiliations

Soon will be listed here.

Abstract

The liver is an organ consisting of the largest reticulo-endothelial cell network in the body and playing an important role in host defense against invading microorganisms. The organ is comprised of parenchymal cells and many different types of non-parenchymal cells, all of which play a significant role. Even biliary epithelial cells are not only the target in autoimmune liver diseases but also have central role in orchestrating several immune cells involved in both innate and acquired immunity. Tissue damage caused by various agents results in inflammation, necrosis, fibrosis, and, eventually, distortion of normal hepatic architecture, cirrhosis, and functional deterioration.

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