Absolute Stereostructures of Chaetomugilins G and H Produced by a Marine-fish-derived Chaetomium Species

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 2009 May 23

PMID 19461670

Citations 9

Authors

Takeshi Yamada

Muroga Yasuhide

Hirohumi Shigeta

Atsushi Numata

Reiko Tanaka

Affiliations

Soon will be listed here.

Abstract

Chaetomugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and chemical transformation. In addition, the absolute configuration of chaetoviridin C was established by derivatization from chaetomugilin A. These compounds exhibited a growth inhibitory activity against cultured P388, HL-60, L1210 and KB cells.

Citing Articles

Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.

Gao Y, Wang J, Meesakul P, Zhou J, Liu J, Liu S Mar Drugs. 2024; 22(2).

PMID: 38393041 PMC: 10890532. DOI: 10.3390/md22020070.

Key insights into secondary metabolites from various Chaetomium species.

Dwibedi V, Rath S, Jain S, Martinez-Argueta N, Prakash R, Saxena S Appl Microbiol Biotechnol. 2023; 107(4):1077-1093.

PMID: 36648526 PMC: 9843691. DOI: 10.1007/s00253-023-12365-y.

A Review on Bioactive Compounds from Marine-Derived Species.

Tian Y, Li Y J Microbiol Biotechnol. 2022; 32(5):541-550.

PMID: 35586928 PMC: 9628867. DOI: 10.4014/jmb.2201.01007.

Chaetomugilins and Chaetoviridins-Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular Dynamics.

Omar A, Mohamed G, Ibrahim S J Fungi (Basel). 2022; 8(2).

PMID: 35205880 PMC: 8875349. DOI: 10.3390/jof8020127.

Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents.

Giddings L, Newman D Mar Drugs. 2022; 20(1).

PMID: 35049917 PMC: 8781577. DOI: 10.3390/md20010062.