The Centrosome and Asymmetric Cell Division

Overview

Journal Prion

Specialty Biochemistry

Date 2009 May 22

PMID 19458491

Citations 18

Authors

Yukiko M Yamashita

Affiliations

Soon will be listed here.

Abstract

Asymmetric stem cell division is a mechanism widely employed by the cell to maintain tissue homeostasis, resulting in the production of one stem cell and one differentiating cell. However, asymmetric cell division is not limited to stem cells and is widely observed even in unicellular organisms as well as in cells that make up highly complex tissues. In asymmetric cell division, cells must organize their intracellular components along the axis of asymmetry (sometimes in the context of extracellular architecture). Recent studies have described cell asymmetry in many cell types and in many cases such asymmetry involves the centrosome (or spindle pole body in yeast) as the center of cytoskeleton organization. In this review, I summarize recent discoveries in cellular polarity that lead to an asymmetric outcome, with a focus on centrosome function.

Citing Articles

Isolation of Mitotic Centrosomes from Cultured Human Cells.

Miyazawa M, Yamamoto S, Goyama S, Kitagawa D Methods Mol Biol. 2024; 2872:233-244.

PMID: 39616580 DOI: 10.1007/978-1-0716-4224-5_16.

Modulating DNA Polα Enhances Cell Reprogramming Across Species.

Ranjan R, Ma B, Gleason R, Liao Y, Bi Y, Davis B bioRxiv. 2024; .

PMID: 39345551 PMC: 11429986. DOI: 10.1101/2024.09.19.613993.

Cellular senescence, rejuvenation and potential immortality.

Sheldrake A Proc Biol Sci. 2022; 289(1970):20212434.

PMID: 35232226 PMC: 8889192. DOI: 10.1098/rspb.2021.2434.

With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making.

Sullenberger C, Vasquez-Limeta A, Kong D, Loncarek J Cells. 2020; 9(6).

PMID: 32526902 PMC: 7349492. DOI: 10.3390/cells9061429.

Adipose Stem Cell Translational Applications: From Bench-to-Bedside.

Argentati C, Morena F, Bazzucchi M, Armentano I, Emiliani C, Martino S Int J Mol Sci. 2018; 19(11).

PMID: 30400641 PMC: 6275042. DOI: 10.3390/ijms19113475.

References

Pereira G, Tanaka T, Nasmyth K, Schiebel E . Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex. EMBO J. 2001; 20(22):6359-70. PMC: 125717. DOI: 10.1093/emboj/20.22.6359. View

Rebollo E, Sampaio P, Januschke J, Llamazares S, Varmark H, Gonzalez C . Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Dev Cell. 2007; 12(3):467-74. DOI: 10.1016/j.devcel.2007.01.021. View

Rosenblatt J, Cramer L, Baum B, McGee K . Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly. Cell. 2004; 117(3):361-72. DOI: 10.1016/s0092-8674(04)00341-1. View

Sinclair D, Guarente L . Extrachromosomal rDNA circles--a cause of aging in yeast. Cell. 1998; 91(7):1033-42. DOI: 10.1016/s0092-8674(00)80493-6. View

Rusan N, Rogers G . Centrosome function: sometimes less is more. Traffic. 2009; 10(5):472-81. DOI: 10.1111/j.1600-0854.2009.00880.x. View

Doxsey S, Zimmerman W, Mikule K . Centrosome control of the cell cycle. Trends Cell Biol. 2005; 15(6):303-11. DOI: 10.1016/j.tcb.2005.04.008. View

Dubreuil V, Marzesco A, Corbeil D, Huttner W, Wilsch-Brauninger M . Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol. 2007; 176(4):483-95. PMC: 2063983. DOI: 10.1083/jcb.200608137. View

Pereira G, Schiebel E . The role of the yeast spindle pole body and the mammalian centrosome in regulating late mitotic events. Curr Opin Cell Biol. 2001; 13(6):762-9. DOI: 10.1016/s0955-0674(00)00281-7. View

Pohl C, Jentsch S . Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol. 2008; 11(1):65-70. DOI: 10.1038/ncb1813. View

10.

Yamashita Y, Mahowald A, Perlin J, Fuller M . Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science. 2007; 315(5811):518-21. PMC: 2563045. DOI: 10.1126/science.1134910. View

11.

Delattre M, Gonczy P . The arithmetic of centrosome biogenesis. J Cell Sci. 2004; 117(Pt 9):1619-30. DOI: 10.1242/jcs.01128. View

12.

Piel M, Nordberg J, Euteneuer U, Bornens M . Centrosome-dependent exit of cytokinesis in animal cells. Science. 2001; 291(5508):1550-3. DOI: 10.1126/science.1057330. View

13.

Rusan N, Peifer M . A role for a novel centrosome cycle in asymmetric cell division. J Cell Biol. 2007; 177(1):13-20. PMC: 2064101. DOI: 10.1083/jcb.200612140. View

14.

Pereira G, Schiebel E . Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol Cell. 2005; 19(2):209-21. DOI: 10.1016/j.molcel.2005.05.030. View

15.

Kosodo Y, Roper K, Haubensak W, Marzesco A, Corbeil D, Huttner W . Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J. 2004; 23(11):2314-24. PMC: 419905. DOI: 10.1038/sj.emboj.7600223. View

16.

Singhvi A, Garriga G . Asymmetric divisions, aggresomes and apoptosis. Trends Cell Biol. 2008; 19(1):1-7. PMC: 2814184. DOI: 10.1016/j.tcb.2008.10.004. View

17.

Gromley A, Yeaman C, Rosa J, Redick S, Chen C, Mirabelle S . Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Cell. 2005; 123(1):75-87. DOI: 10.1016/j.cell.2005.07.027. View

18.

DAquino K, Monje-Casas F, Paulson J, Reiser V, Charles G, Lai L . The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell. 2005; 19(2):223-34. DOI: 10.1016/j.molcel.2005.06.005. View

19.

Huisman S, Segal M . Cortical capture of microtubules and spindle polarity in budding yeast - where's the catch?. J Cell Sci. 2005; 118(Pt 3):463-71. DOI: 10.1242/jcs.01650. View

20.

Marzesco A, Janich P, Wilsch-Brauninger M, Dubreuil V, Langenfeld K, Corbeil D . Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci. 2005; 118(Pt 13):2849-58. DOI: 10.1242/jcs.02439. View