The Amyloid Hypothesis for Alzheimer's Disease: a Critical Reappraisal

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 2009 May 22

PMID 19457065

Citations 316

Authors

John Hardy

Affiliations

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Abstract

The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.

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