Nutrigenomic Analysis of Diet-gene Interactions on Functional Supplements for Weight Management

Overview

Journal Curr Genomics

Publisher Bentham Science Publishers

Date 2009 May 20

PMID 19452041

Citations 6

Authors

Francis C Lau

Manashi Bagchi

Chandan Sen

Sashwati Roy

Debasis Bagchi

Affiliations

Soon will be listed here.

Abstract

Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nutrigenomics, a new discipline in the field of nutritional research. Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic. According to the World Health Organization, more than 60% of the global disease burden will be attributed to chronic disorders associated with obesity by 2020. Meanwhile in the US, the prevalence of obesity has doubled in adults and tripled in children during the past three decades. In this regard, a number of natural dietary supplements and micronutrients have been studied for their potential in weight management. Among these supplements, (-)-hydroxycitric acid (HCA), a natural extract isolated from the dried fruit rind of Garcinia cambogia, and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss. Utilizing cDNA microarrays, we demonstrated for the first time that HCA-supplementation altered the expression of genes involved in lipolytic and adipogenic pathways in adipocytes from obese women and up-regulated the expression of serotonin receptor gene in the abdominal fat of rats. Similarly, we showed that NBC-supplementation up-regulated the expression of myogenic genes while suppressed the expression of genes that are highly expressed in brown adipose tissue in diabetic obese mice. The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-the-art nutrigenomic technologies will be systematically discussed in this review.

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References

Grant K, Chandler R, Castle A, Ivy J . Chromium and exercise training: effect on obese women. Med Sci Sports Exerc. 1997; 29(8):992-8. DOI: 10.1097/00005768-199708000-00003. View

Ordovas J . The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins. Proc Nutr Soc. 2004; 63(1):145-52. DOI: 10.1079/PNS2003313. View

Bachman K . Obesity, weight management, and health care costs: a primer. Dis Manag. 2007; 10(3):129-37. DOI: 10.1089/dis.2007.103643. View

Lin J, Handschin C, Spiegelman B . Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005; 1(6):361-70. DOI: 10.1016/j.cmet.2005.05.004. View

Anderson J, Konz E . Obesity and disease management: effects of weight loss on comorbid conditions. Obes Res. 2001; 9 Suppl 4:326S-334S. DOI: 10.1038/oby.2001.138. View

Mertz W . Effects and metabolism of glucose tolerance factor. Nutr Rev. 1975; 33(5):129-35. DOI: 10.1111/j.1753-4887.1975.tb07105.x. View

Soni M, Burdock G, Preuss H, Stohs S, Ohia S, Bagchi D . Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol. 2004; 42(9):1513-29. DOI: 10.1016/j.fct.2004.04.014. View

Gloerich J, Ruiter J, Van den Brink D, Ofman R, Ferdinandusse S, Wanders R . Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. FEBS Lett. 2006; 580(8):2092-6. DOI: 10.1016/j.febslet.2006.03.011. View

Corthesy-Theulaz I, den Dunnen J, Ferre P, Geurts J, Muller M, van Belzen N . Nutrigenomics: the impact of biomics technology on nutrition research. Ann Nutr Metab. 2005; 49(6):355-65. DOI: 10.1159/000088315. View

10.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

11.

Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M . Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expr. 2004; 11(5-6):251-62. PMC: 5991152. DOI: 10.3727/000000003783992289. View

12.

Rink C, Roy S, Khanna S, Rink T, Bagchi D, Sen C . Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium. Physiol Genomics. 2006; 27(3):370-9. DOI: 10.1152/physiolgenomics.00071.2006. View

13.

Caballero B . The global epidemic of obesity: an overview. Epidemiol Rev. 2007; 29:1-5. DOI: 10.1093/epirev/mxm012. View

14.

Wittert G, Turnbull H, Hope P, Morley J, Horowitz M . Leptin prevents obesity induced by a high-fat diet after diet-induced weight loss in the marsupial S. crassicaudata. Am J Physiol Regul Integr Comp Physiol. 2004; 286(4):R734-9. DOI: 10.1152/ajpregu.00240.2003. View

15.

Preuss H, Bagchi D, Bagchi M, Rao C, Dey D, Satyanarayana S . Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab. 2004; 6(3):171-80. DOI: 10.1111/j.1462-8902.2004.00328.x. View

16.

Wei Q, Doris P, Pollizotto M, Boerwinkle E, Jacobs Jr D, Siscovick D . Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. Atherosclerosis. 2006; 190(1):26-34. DOI: 10.1016/j.atherosclerosis.2006.02.021. View

17.

Pittler M, Ernst E . Dietary supplements for body-weight reduction: a systematic review. Am J Clin Nutr. 2004; 79(4):529-36. DOI: 10.1093/ajcn/79.4.529. View

18.

Flegal K, Carroll M, Ogden C, Johnson C . Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002; 288(14):1723-7. DOI: 10.1001/jama.288.14.1723. View

19.

Maquoi E, Demeulemeester D, Voros G, Collen D, Lijnen H . Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation. Thromb Haemost. 2003; 89(4):696-704. View

20.

Lee C, North K, Bray M, Fornage M, Seubert J, Newman J . Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet. 2006; 15(10):1640-9. PMC: 2040335. DOI: 10.1093/hmg/ddl085. View