The Human Leukocyte Antigen Class I Genes in Nasopharyngeal Carcinoma Risk

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2009 May 19

PMID 19449168

Citations 7

Authors

Elham Hassen

Ghandri Nahla

Noureddine Bouaouina

Lotfi Chouchane

Affiliations

Soon will be listed here.

Abstract

Nasopharyngeal carcinoma (NPC) is a virally associated cancer which is highly prevalent in Southeast Asia and North Africa. Several linkage analysis studies suggested the association of susceptibility HLA (Human Leukocyte Antigen) alleles and haplotypes with NPC development. The HLA system is very polymorphic and according to the ethnic group studied, it has been found to have the capacity to confer susceptibility or resistance to NPC. Our aim was to review the most important described genetic associations of HLA class I in NPC and to comment on the inconsistent associations found in the different NPC incidence areas. We believe that the mechanisms of these associations may involve HLA genes through the differential capacity of each allele to present antigens. However, because HLA genes contain various linked candidate genes, HLA-NPC associations should be carefully interpreted.

Citing Articles

Associations of Human Leukocyte Antigen-DRB1 Alleles with Nasopharyngeal Carcinoma and Its Clinical Significance in Xinjiang Uyghur Autonomous Region of China.

Geng X, Hu Y, Dong T, Wang R Chin Med J (Engl). 2016; 129(11):1347-54.

PMID: 27231174 PMC: 4894047. DOI: 10.4103/0366-6999.182833.

Molecular docking to identify associations between drugs and class I human leukocyte antigens for predicting idiosyncratic drug reactions.

Luo H, Du T, Zhou P, Yang L, Mei H, Ng H Comb Chem High Throughput Screen. 2015; 18(3):296-304.

PMID: 25747444 PMC: 4581727. DOI: 10.2174/1386207318666150305144015.

Large scale analysis of phenotype-pathway relationships based on GWAS results.

Brodie A, Tovia-Brodie O, Ofran Y PLoS One. 2014; 9(7):e100887.

PMID: 25007247 PMC: 4090199. DOI: 10.1371/journal.pone.0100887.

How genome-wide SNP-SNP interactions relate to nasopharyngeal carcinoma susceptibility.

Su W, Shugart Y, Chang K, Tsang N, Tse K, Chang Y PLoS One. 2013; 8(12):e83034.

PMID: 24376627 PMC: 3871583. DOI: 10.1371/journal.pone.0083034.

HLA Class I Allele Frequencies in Southern Iranian Women with Breast Cancer.

Razmkhah M, Ghaderi A Iran J Basic Med Sci. 2013; 16(2):140-3.

PMID: 24298381 PMC: 3843856.

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