[Th17 Cells - a New Proinflammatory T Cell Population and Its Role in Rheumatologic Autoimmune Diseases]

Overview

Journal Z Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2009 May 19

PMID 19449017

Citations 1

Authors

J Leipe

A Skapenko

H Schulze-Koops

Affiliations

Soon will be listed here.

Abstract

CD4 T cells play a major role in the development and persistence of autoimmune rheumatic diseases. The recent identification of IL-17-producing Th17 cells as a potent proinflammatory subset extends the understanding of pathophysiological processes not explained by the Th1/Th2 dichotomy. The recent data from human studies discussed in this article indicate an important pathogenic function for Th17 cells and Th17-derived IL-17 suggesting that therapies targeting Th17 cells/IL-17 may be of potential use in the treatment of those diseases.

Citing Articles

[Effector T cells].

Leipe J, Chang H Z Rheumatol. 2015; 74(1):14-9.

PMID: 25608674 DOI: 10.1007/s00393-014-1441-9.

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