New Genetic Lineage of Tula Hantavirus in Microtus Arvalis Obscurus in Eastern Kazakhstan

Overview

Journal Open Virol J

Publisher Bentham Open

Date 2009 May 15

PMID 19440462

Citations 6

Authors

Angelina Plyusnina

Juha Laakkonen

Jukka Niemimaa

Heikki Henttonen

Alexander Plyusnin

Affiliations

Soon will be listed here.

Abstract

Genomic sequences of Tula (TULV) hantavirus were recovered from tissue samples of European common voles Microtus arvalis (subspecies obscurus) captured in Kazakhstan, Central Asia. Phylogenetic analysis of the S genomic segment of Kazakh TULV strains showed that they form distinct, well supported genetic lineage and share a more ancient common ancestor with two Russian lineages of TULV. The deduced sequence of the nucleocapsid (N) protein of Kazakh TULV strains carried specific amino acid signature: T274Q276T281. The Microtus arvalis group includes several sibling species and/or subspecies in Eurasia, indicating recent and ongoing evolutionary radiation. Our data on TULV lineages in Central Asia, the region not studied for hantaviruses earlier, highlight the diversity of both Microtus host and the virus and also their co-evolution.

Citing Articles

Hantavirus antibody seroprevalence and risk factors among adults in West Kazakhstan, 2023.

Gubareva U, Horth R, Nabirova D, Tukhanova N, Utegenova E, Shapiyeva Z Front Public Health. 2025; 12:1519117.

PMID: 39886389 PMC: 11780674. DOI: 10.3389/fpubh.2024.1519117.

Molecular Characterisation and Phylogeny of Tula Virus in Kazakhstan.

Tukhanova N, Shin A, Turebekov N, Nurmakhanov T, Abdiyeva K, Shevtsov A Viruses. 2022; 14(6).

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Spatial and Temporal Dynamics and Molecular Evolution of in German Vole Populations.

Schmidt S, Reil D, Jeske K, Drewes S, Rosenfeld U, Fischer S Viruses. 2021; 13(6).

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Molecular evidence of Tula virus in Microtus obscurus in the region of Yili, Xinjiang, China.

Guo G, Guo B, Wu X, Wang Y, Bao J, Ren Y BMC Infect Dis. 2019; 19(1):527.

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Global Diversity and Distribution of Hantaviruses and Their Hosts.

Milholland M, Castro-Arellano I, Suzan G, Garcia-Pena G, Lee Jr T, Rohde R Ecohealth. 2018; 15(1):163-208.

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