Postsynaptic Scaffolds for Nicotinic Receptors on Neurons

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2009 May 13

PMID 19434056

Citations 9

Authors

Robert A Neff 3rd

David Gomez-Varela

Catarina C Fernandes

Darwin K Berg

Affiliations

Soon will be listed here.

Abstract

Complex postsynaptic scaffolds determine the structure and signaling capabilities of glutamatergic synapses. Recent studies indicate that some of the same scaffold components contribute to the formation and function of nicotinic synapses on neurons. PDZ-containing proteins comprising the PSD-95 family co-localize with nicotinic acetylcholine receptors (nAChRs) and mediate downstream signaling in the neurons. The PDZ-proteins also promote functional nicotinic innervation of the neurons, as does the scaffold protein APC and transmembrane proteins such as neuroligin and the EphB2 receptor. In addition, specific chaperones have been shown to facilitate nAChR assembly and transport to the cell surface. This review summarizes recent results in these areas and raises questions for the future about the mechanism and synaptic role of nAChR trafficking.

Citing Articles

Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific α7 nAChRs KD Mice.

Batool S, Akhter B, Zaidi J, Visser F, Petrie G, Hill M Cells. 2021; 10(12).

PMID: 34943798 PMC: 8699470. DOI: 10.3390/cells10123286.

An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors.

Ferns M Molecules. 2021; 26(11).

PMID: 34063759 PMC: 8196675. DOI: 10.3390/molecules26113065.

Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel.

Hu H, Howard R, Bastolla U, Lindahl E, Delarue M Proc Natl Acad Sci U S A. 2020; 117(24):13437-13446.

PMID: 32482881 PMC: 7306758. DOI: 10.1073/pnas.1922701117.

Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.

Elnagar M, Walls A, Helal G, Hamada F, Thomsen M, Jensen A PLoS One. 2017; 12(12):e0189513.

PMID: 29261717 PMC: 5738045. DOI: 10.1371/journal.pone.0189513.

Preparation of synaptic plasma membrane and postsynaptic density proteins using a discontinuous sucrose gradient.

Bermejo M, Milenkovic M, Salahpour A, Ramsey A J Vis Exp. 2014; (91):e51896.

PMID: 25226023 PMC: 4828025. DOI: 10.3791/51896.

References

Ross B, Conroy W . Capabilities of neurexins in the chick ciliary ganglion. Dev Neurobiol. 2007; 68(3):409-19. DOI: 10.1002/dneu.20598. View

Khiroug L, Giniatullin R, Klein R, Fayuk D, Yakel J . Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons. J Neurosci. 2003; 23(27):9024-31. PMC: 6740844. View

Picciotto M, Zoli M, Lena C, BESSIS A, Lallemand Y, Le Novere N . Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 1995; 374(6517):65-7. DOI: 10.1038/374065a0. View

Triana-Baltzer G, Liu Z, Gounko N, Berg D . Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons. Mol Cell Neurosci. 2008; 39(1):74-82. PMC: 2600484. DOI: 10.1016/j.mcn.2008.05.017. View

Rosenberg M, Yang F, Giovanni M, Mohn J, Temburni M, Jacob M . Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Mol Cell Neurosci. 2008; 38(2):138-52. PMC: 2502068. DOI: 10.1016/j.mcn.2008.02.006. View

Maggi L, Le Magueresse C, Changeux J, Cherubini E . Nicotine activates immature "silent" connections in the developing hippocampus. Proc Natl Acad Sci U S A. 2003; 100(4):2059-64. PMC: 149958. DOI: 10.1073/pnas.0437947100. View

Elias G, Funke L, Stein V, Grant S, Bredt D, Nicoll R . Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron. 2006; 52(2):307-20. DOI: 10.1016/j.neuron.2006.09.012. View

Marks M, Stitzel J, Collins A . Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. J Pharmacol Exp Ther. 1985; 235(3):619-28. View

Vallejo Y, Buisson B, Bertrand D, Green W . Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism. J Neurosci. 2005; 25(23):5563-72. PMC: 2246082. DOI: 10.1523/JNEUROSCI.5240-04.2005. View

10.

Dajas-Bailador F, Wonnacott S . Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol Sci. 2004; 25(6):317-24. DOI: 10.1016/j.tips.2004.04.006. View

11.

McGehee D, Heath M, Gelber S, Devay P, Role L . Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 1995; 269(5231):1692-6. DOI: 10.1126/science.7569895. View

12.

Young S, Poo M . Rapid lateral diffusion of extrajunctional acetylcholine receptors in the developing muscle membrane of Xenopus tadpole. J Neurosci. 1983; 3(1):225-31. PMC: 6564594. View

13.

Ehrlich I, Malinow R . Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci. 2004; 24(4):916-27. PMC: 6729816. DOI: 10.1523/JNEUROSCI.4733-03.2004. View

14.

Wang F, Nelson M, Kuryatov A, Olale F, Cooper J, Keyser K . Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. J Biol Chem. 1998; 273(44):28721-32. DOI: 10.1074/jbc.273.44.28721. View

15.

Newpher T, Ehlers M . Glutamate receptor dynamics in dendritic microdomains. Neuron. 2008; 58(4):472-97. PMC: 2572138. DOI: 10.1016/j.neuron.2008.04.030. View

16.

Sargent P . The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci. 1993; 16:403-43. DOI: 10.1146/annurev.ne.16.030193.002155. View

17.

Millar N . RIC-3: a nicotinic acetylcholine receptor chaperone. Br J Pharmacol. 2008; 153 Suppl 1:S177-83. PMC: 2268041. DOI: 10.1038/sj.bjp.0707661. View

18.

Elias G, Elias L, Apostolides P, Kriegstein A, Nicoll R . Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development. Proc Natl Acad Sci U S A. 2008; 105(52):20953-8. PMC: 2634944. DOI: 10.1073/pnas.0811025106. View

19.

Temburni M, Rosenberg M, Pathak N, McConnell R, Jacob M . Neuronal nicotinic synapse assembly requires the adenomatous polyposis coli tumor suppressor protein. J Neurosci. 2004; 24(30):6776-84. PMC: 6729726. DOI: 10.1523/JNEUROSCI.1826-04.2004. View

20.

Treinin M . RIC-3 and nicotinic acetylcholine receptors: biogenesis, properties, and diversity. Biotechnol J. 2008; 3(12):1539-47. DOI: 10.1002/biot.200800179. View