Aging of the Striatum: Mechanisms and Interventions

Overview

Journal Age (Dordr)

Publisher Springer

Specialty Geriatrics

Date 2009 May 9

PMID 19424849

Citations 11

Authors

Hiroyuki Umegaki

George S Roth

Donald K Ingram

Affiliations

Soon will be listed here.

Abstract

Motor function declines with increasing adult age. Proper regulation of the balance between dopamine (DA) and acetylcholine (ACh) in the striatum has been shown to be fundamentally important for motor control. Although other factors can also contribute to this age-associated decline, a decrease in the concentration and binding potential of the DA D(2) receptor subtype in the striatum, especially in the cholinergic interneurons, are involved in the mechanism. Our studies have shown that gene transfer of the DA D(2) receptor subtype with adenoviral vectors is effective in ameliorating age-associated functional decline of the striatal cholinergic interneurons. These achievements confirm that an age-associated decrease of D(2)R contributes functional alteration of the interaction of DA and ACh in the striatum and demonstrate that these age-associated changes indeed are modifiable.

Citing Articles

Feature attention graph neural network for estimating brain age and identifying important neural connections in mouse models of genetic risk for Alzheimer's disease.

Moon H, Mahzarnia A, Stout J, Anderson R, Badea C, Badea A bioRxiv. 2024; .

PMID: 38168445 PMC: 10760088. DOI: 10.1101/2023.12.13.571574.

Aging in nucleus accumbens and its impact on alcohol use disorders.

Konar-Nie M, Guzman-Castillo A, Armijo-Weingart L, Aguayo L Alcohol. 2022; 107:73-90.

PMID: 36087859 PMC: 10350931. DOI: 10.1016/j.alcohol.2022.08.004.

Mapping microstructural gradients of the human striatum in normal aging and Parkinson's disease.

Drori E, Berman S, Mezer A Sci Adv. 2022; 8(28):eabm1971.

PMID: 35857492 PMC: 9286505. DOI: 10.1126/sciadv.abm1971.

Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons.

Abdollahi M, Fahnestock M Int J Mol Sci. 2022; 23(12).

PMID: 35743300 PMC: 9224520. DOI: 10.3390/ijms23126853.

Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders.

Mitra S, Banik A, Saurabh S, Maulik M, Khatri S J Neurosci. 2022; 42(10):1888-1907.

PMID: 35027409 PMC: 8916763. DOI: 10.1523/JNEUROSCI.0998-21.2022.

References

Ogawa N, Asanuma M, Kondo Y, Nishibayashi S, Mori A . Reduced choline acetyltransferase activity and muscarinic M1 receptor levels in aged Fisher 344 rat brains did not parallel their respective mRNA levels. Brain Res. 1994; 658(1-2):87-92. DOI: 10.1016/s0006-8993(09)90013-0. View

Marshall J, Berrios N . Movement disorders of aged rats: reversal by dopamine receptor stimulation. Science. 1979; 206(4417):477-9. DOI: 10.1126/science.504992. View

Kubota Y, Inagaki S, Shimada S, Kito S, Eckenstein F, Tohyama M . Neostriatal cholinergic neurons receive direct synaptic inputs from dopaminergic axons. Brain Res. 1987; 413(1):179-84. DOI: 10.1016/0006-8993(87)90167-3. View

Joseph J, Roth G . Altered striatal dopaminergic and cholinergic reciprocal inhibitory control and motor behavioral decrements in senescence. Ann N Y Acad Sci. 1988; 521:110-22. DOI: 10.1111/j.1749-6632.1988.tb35269.x. View

Zhang L, Ravipati A, Joseph J, Roth G . Aging-related changes in rat striatal D2 receptor mRNA-containing neurons: a quantitative nonradioactive in situ hybridization study. J Neurosci. 1995; 15(3 Pt 1):1735-40. PMC: 6578128. View

Fahn S . Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci. 2003; 991:1-14. DOI: 10.1111/j.1749-6632.2003.tb07458.x. View

Ogawa O, Umegaki H, Ishiwata K, Asai Y, Ikari H, Oda K . In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography. Neuroreport. 2000; 11(4):743-8. DOI: 10.1097/00001756-200003200-00018. View

Chang H . Dopamine-acetylcholine interaction in the rat striatum: a dual-labeling immunocytochemical study. Brain Res Bull. 1988; 21(2):295-304. DOI: 10.1016/0361-9230(88)90244-4. View

Pickel V, Chan J . Plasmalemmal appositions between cholinergic and non-cholinergic neurons in rat caudate-putamen nuclei. Neuroscience. 1991; 41(2-3):459-72. DOI: 10.1016/0306-4522(91)90341-k. View

10.

Dutta C, Hadley E, Lexell J . Sarcopenia and physical performance in old age: overview. Muscle Nerve Suppl. 1997; 5:S5-9. View

11.

Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman R . Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science. 2000; 289(5479):633-7. DOI: 10.1126/science.289.5479.633. View

12.

Umegaki H, Ishiwata K, Ogawa O, Ingram D, Roth G, Oda K . Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study. Neuroscience. 2003; 121(2):479-86. DOI: 10.1016/s0306-4522(03)00489-5. View

13.

Calabresi P, Centonze D, Gubellini P, Pisani A, Bernardi G . Acetylcholine-mediated modulation of striatal function. Trends Neurosci. 2000; 23(3):120-6. DOI: 10.1016/s0166-2236(99)01501-5. View

14.

Pisani A, Bonsi P, Picconi B, Tolu M, Giacomini P, Scarnati E . Role of tonically-active neurons in the control of striatal function: cellular mechanisms and behavioral correlates. Prog Neuropsychopharmacol Biol Psychiatry. 2001; 25(1):211-30. DOI: 10.1016/s0278-5846(00)00153-6. View

15.

deBoer P, Heeringa M, Abercrombie E . Spontaneous release of acetylcholine in striatum is preferentially regulated by inhibitory dopamine D2 receptors. Eur J Pharmacol. 1996; 317(2-3):257-62. DOI: 10.1016/s0014-2999(96)00761-3. View

16.

Zambrzycka A, Alberghina M, Strosznajder J . Effects of aging and amyloid-beta peptides on choline acetyltransferase activity in rat brain. Neurochem Res. 2002; 27(4):277-81. DOI: 10.1023/a:1014951010834. View

17.

Han Z, Kuyatt B, Kochman K, Desouza E, Roth G . Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum. Brain Res. 1989; 498(2):299-307. DOI: 10.1016/0006-8993(89)91108-6. View

18.

Stark A, Pakkenberg B . Histological changes of the dopaminergic nigrostriatal system in aging. Cell Tissue Res. 2004; 318(1):81-92. DOI: 10.1007/s00441-004-0972-9. View

19.

Dorfman L, Bosley T . Age-related changes in peripheral and central nerve conduction in man. Neurology. 1979; 29(1):38-44. DOI: 10.1212/wnl.29.1.38. View

20.

Dimova R, VUILLET J, Nieoullon A, Kerkerian-Le Goff L . Ultrastructural features of the choline acetyltransferase-containing neurons and relationships with nigral dopaminergic and cortical afferent pathways in the rat striatum. Neuroscience. 1993; 53(4):1059-71. DOI: 10.1016/0306-4522(93)90489-3. View