The Role of the Platelet-rich Plasma in Accelerating the Wound-healing Process and Recovery in Patients Being Operated for Pilonidal Sinus Disease: Preliminary Results

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2009 May 9

PMID 19424751

Citations 20

Authors

Michail Spyridakis

Gregory Christodoulidis

Constantine Chatzitheofilou

Dimitris Symeonidis

Konstantinos Tepetes

Affiliations

Soon will be listed here.

Abstract

Background: Because of the poor quality of life that results from the open technique (open excision and packing) for surgically treating pilonidal cyst disease, several alternatives that accelerate the wound-healing process have been proposed. This study aimed to evaluate the effect of platelet-derived growth factors on the healing process.

Methods: Fifty-two patients with pilonidal sinus disease who underwent open excision and secondary closure of the surgical wound (n = 22) or additional local postoperative infusion of platelet-derived growth factors (n = 30) were evaluated. Duration of total wound healing and time to return to normal activities were evaluated. Quality of life of patients in each group was assessed via a stabilized questionnaire.

Results: Wound-healing rates were much greater for the platelet group (p < 0.01). Complete healing of the surgical wound required 24 days for the platelet group while the respective time for the control group was more than 30 days (p < 0.01). Patients in the platelet group returned to their normal activities around the postoperative day 17 when mean wound volume was about 10 cc, while control group patients managed to do so around the postoperative day 25.

Conclusions: These data provide evidence that the use of platelet-derived growth factors directly to the surgical wound enhances the healing process resulting in faster recovery of patients surgically treated for pilonidal sinus disease.

Citing Articles

The power of platelet-rich plasma on operated pilonidal disease: a prospective randomized controlled trial.

Chousein B, Olcucuoglu E, Kaya I Ann Surg Treat Res. 2025; 108(2):124-134.

PMID: 39944926 PMC: 11813548. DOI: 10.4174/astr.2025.108.2.124.

Platelet-rich plasma for pilonidal disease: a systematic review.

Zhuang Y, Feng W J Int Med Res. 2023; 51(12):3000605231216590.

PMID: 38141657 DOI: 10.1177/03000605231216590.

The Effect of Platelet-Rich Plasma on Healing Time in Patients Following Pilonidal Sinus Surgery: A Systematic Review.

Khan Q, Baig H, Al Failakawi A, Majeed S, Khan M, Lucocq J Cureus. 2022; 14(8):e27777.

PMID: 36106230 PMC: 9450803. DOI: 10.7759/cureus.27777.

Platelet-Rich Plasma (PRP) for Sacrococcygeal Pilonidal Disease: An Updated Systematic Review and Meta-Analysis.

Brewer C, Correia I, Miranda B World J Surg. 2022; 46(12):2910-2918.

PMID: 36064868 DOI: 10.1007/s00268-022-06711-w.

Platelet-rich plasma treatment improves postoperative recovery in patients with pilonidal sinus disease: a randomized controlled clinical trial.

Boztug C, Akyol T, Benlice C, Koc M, Doganay Erdogan B, Ozcebe O BMC Surg. 2021; 21(1):373.

PMID: 34670534 PMC: 8529773. DOI: 10.1186/s12893-021-01370-5.

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