Long-lived Ames Dwarf Mice Are Resistant to Chemical Stressors

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2009 May 6

PMID 19414510

Citations 60

Authors

Alex F Bokov

Merry L Lindsey

Christina Khodr

Marian R Sabia

Arlan Richardson

Affiliations

Soon will be listed here.

Abstract

To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F(2)-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.

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References

Fukushima T, Yamada K, Isobe A, Shiwaku K, Yamane Y . Mechanism of cytotoxicity of paraquat. I. NADH oxidation and paraquat radical formation via complex I. Exp Toxicol Pathol. 1993; 45(5-6):345-9. DOI: 10.1016/S0940-2993(11)80424-0. View

Gautsch T, Kandl S, Donovan S, Layman D . Response of the IGF-I system to prolonged undernutrition and its involvement in somatic and skeletal muscle growth retardation in rats. Growth Dev Aging. 1998; 62(1-2):13-25. View

Sornson M, Wu W, Dasen J, FLYNN S, Norman D, OConnell S . Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature. 1996; 384(6607):327-33. DOI: 10.1038/384327a0. View

Larsen P . Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1993; 90(19):8905-9. PMC: 47469. DOI: 10.1073/pnas.90.19.8905. View

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

Iwasaki K, GLEISER C, MASORO E, McMahan C, Seo E, Yu B . Influence of the restriction of individual dietary components on longevity and age-related disease of Fischer rats: the fat component and the mineral component. J Gerontol. 1988; 43(1):B13-21. DOI: 10.1093/geronj/43.1.b13. View

Ikeno Y, Bronson R, Hubbard G, Lee S, Bartke A . Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci. 2003; 58(4):291-6. DOI: 10.1093/gerona/58.4.b291. View

Chandrashekar V, Bartke A . Induction of endogenous insulin-like growth factor-I secretion alters the hypothalamic-pituitary-testicular function in growth hormone-deficient adult dwarf mice. Biol Reprod. 1993; 48(3):544-51. DOI: 10.1095/biolreprod48.3.544. View

Salmon A, Murakami S, Bartke A, Kopchick J, Yasumura K, Miller R . Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab. 2005; 289(1):E23-9. DOI: 10.1152/ajpendo.00575.2004. View

10.

Bokov A, Chaudhuri A, Richardson A . The role of oxidative damage and stress in aging. Mech Ageing Dev. 2004; 125(10-11):811-26. DOI: 10.1016/j.mad.2004.07.009. View

11.

Brown-Borg H, Johnson W, Rakoczy S, Romanick M . Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice. J Am Aging Assoc. 2013; 24(3):85-96. PMC: 3455482. DOI: 10.1007/s11357-001-0012-6. View

12.

Brown-Borg H, Borg K, Meliska C, Bartke A . Dwarf mice and the ageing process. Nature. 1996; 384(6604):33. DOI: 10.1038/384033a0. View

13.

Klass M, Nguyen P, Dechavigny A . Age-correlated changes in the DNA template in the nematode Caenorhabditis elegans. Mech Ageing Dev. 1983; 22(3-4):253-63. DOI: 10.1016/0047-6374(83)90080-5. View

14.

Rose M, Smith L . Tissue uptake of paraquat and diquat. Gen Pharmacol. 1977; 8(3):173-6. DOI: 10.1016/0306-3623(77)90045-3. View

15.

Roberts 2nd L, Reckelhoff J . Measurement of F(2)-isoprostanes unveils profound oxidative stress in aged rats. Biochem Biophys Res Commun. 2001; 287(1):254-6. DOI: 10.1006/bbrc.2001.5583. View

16.

Argentino D, Dominici F, Munoz M, Al-Regaiey K, Bartke A, Turyn D . Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice. Exp Gerontol. 2005; 40(1-2):27-35. DOI: 10.1016/j.exger.2004.09.005. View

17.

Rikans L, Hornbrook K . Lipid peroxidation, antioxidant protection and aging. Biochim Biophys Acta. 1998; 1362(2-3):116-27. DOI: 10.1016/s0925-4439(97)00067-7. View

18.

Boylston W, Deford J, Papaconstantinou J . Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. Age (Dordr). 2009; 28(2):125-44. PMC: 2464723. DOI: 10.1007/s11357-006-9008-6. View

19.

Gage J . The action of paraquat and diquat on the respiration of liver cell fractions. Biochem J. 1968; 109(5):757-61. PMC: 1187026. DOI: 10.1042/bj1090757. View

20.

Janssen L . Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol. 2001; 280(6):L1067-82. DOI: 10.1152/ajplung.2001.280.6.L1067. View