Myostatin in the Pathophysiology of Skeletal Muscle

Overview

Journal Curr Genomics

Publisher Bentham Science Publishers

Date 2009 May 5

PMID 19412331

Citations 46

Authors

Gilles Carnac

Barbara Vernus

Anne Bonnieu

Affiliations

Soon will be listed here.

Abstract

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Here we discuss the recent developments and the controversies in myostatin research, focusing on the molecular and cellular mechanisms underlying the actions of myostatin on skeletal muscle and the potential therapeutic role of myostatin on muscle-related disorders.

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