Recurrent Febrile Syndromes: What a Rheumatologist Needs to Know

Overview

Journal Nat Rev Rheumatol

Specialty Rheumatology

Date 2009 May 5

PMID 19412191

Citations 17

Authors

Hal M Hoffman

Anna Simon

Affiliations

Soon will be listed here.

Abstract

Rheumatologists are likely to be asked to evaluate patients with recurrent febrile syndromes, so it is important that they are familiar with the clinical and diagnostic features, pathophysiology and therapeutic options for these rare autoinflammatory disorders. These syndromes are all characterized by recurrent episodes of fever and systemic inflammation; however, some syndromes have unique historical and physical features that can help with making a diagnosis. The primary associated morbidity is systemic amyloidosis, usually with renal involvement. Diagnostic testing is mostly limited to genetic testing. NSAIDs, colchicine and corticosteroids have roles in the treatment of some of these disorders, but biologic drugs that target interleukin-1beta are emerging as consistently effective therapies.

Citing Articles

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Davies K, Lonergan B, Patel R, Bukhari M BMJ Case Rep. 2019; 12(7).

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Periodic Fever: a review on clinical, management and guideline for Iranian patients - part I.

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Periodic Fever: A Review on Clinical, Management and Guideline for Iranian Patients - Part II.

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Clinical and genetic characterization of Japanese sporadic cases of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome from a single medical center in Japan.

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