Effect of Subconjunctival Bevacizumab on Primary Pterygium

Overview

Journal Cornea

Specialty Ophthalmology

Date 2009 May 5

PMID 19411971

Citations 20

Authors

Christopher C Teng

Nandesh N Patel

Lawrence Jacobson

Affiliations

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Abstract

Purpose: To investigate the effect of subconjunctival bevacizumab on primary pterygium.

Methods: A patient with an inflamed nasal primary pterygium, refractory to artificial tears and naphazoline, was enrolled in this study. After pretreatment with topical proparacaine and moxifloxacin, 0.05 mL of bevacizumab (1.25 mg/0.05 mL) was injected subconjunctivally at the limbus. Clinical signs of irritation, redness, and vascularization were monitored over 7 weeks.

Results: At 1 week postinjection, irritation and hyperemia showed near-total regression. At week 2, the pterygium maintained this appearance. By week 7, the degree of vascularity and symptoms of irritation had regressed to its preinjection state.

Conclusions: Treatment of primary pterygium with subconjunctival bevacizumab results in a short-term decrease in vascularization and irritation. Further long-term studies should investigate the efficacy of bevacizumab as an adjunct to surgical excision or combined topical treatment targeting other growth factors involved in pterygium pathogenesis.

Citing Articles

Preoperative Intralesional Bevacizumab Injection in Primary Pterygium in Tunisian Patients: A Randomized Controlled Prospective Study.

Sayadi J, Gouider D, Henchiri M, Choura R, Boujelbene N, Abbes I J Curr Ophthalmol. 2023; 34(3):297-304.

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Efficacy of bevacizumab injection after pterygium excision and limbal conjunctival autograft with limbal fixation suture.

Yang H, Lee Y, Hyon J, Kim K, Han S Graefes Arch Clin Exp Ophthalmol. 2020; 258(7):1451-1457.

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A Review of Management Strategies for Nociceptive and Neuropathic Ocular Surface Pain.

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Effect of multiple subconjunctival conbercept injections as an adjuvant to the surgical treatment of pterygium: a prospective randomised comparative 6-month follow-up study.

Zhang J, Tian Q, Zheng T, Chen D, Wang Q, Ke M Eye (Lond). 2019; 34(2):408-414.

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Ghoz N, Britton J, Ross A, Mohammed I, Hogan E, Said D Eye (Lond). 2019; 33(11):1776-1783.

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