Germline Mutation of MicroRNA-125a is Associated with Breast Cancer

Overview

Journal J Med Genet

Specialty Genetics

Date 2009 May 5

PMID 19411564

Citations 48

Authors

W Li

R Duan

F Kooy

S L Sherman

W Zhou

P Jin

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer.

Citing Articles

Engineered mesenchymal stem/stromal cells against cancer.

Shi Y, Zhang J, Li Y, Feng C, Shao C, Shi Y Cell Death Dis. 2025; 16(1):113.

PMID: 39971901 PMC: 11839947. DOI: 10.1038/s41419-025-07443-0.

Human milk EV-miRNAs: a novel biomarker for air pollution exposure during pregnancy.

Holzhausen E, Kupsco A, Chalifour B, Patterson W, Schmidt K, Mokhtari P Environ Res Health. 2023; 1(3):035002.

PMID: 37692372 PMC: 10486183. DOI: 10.1088/2752-5309/ace075.

Pressure pushes tRNA into excited conformational states.

Wang J, Koduru T, Harish B, McCallum S, Larsen K, Patel K Proc Natl Acad Sci U S A. 2023; 120(26):e2215556120.

PMID: 37339210 PMC: 10293818. DOI: 10.1073/pnas.2215556120.

Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms.

Bastami M, Choupani J, Saadatian Z, Zununi Vahed S, Ouladsahebmadarek E, Mansoori Y Int J Mol Sci. 2019; 20(20).

PMID: 31615040 PMC: 6834313. DOI: 10.3390/ijms20205088.

The roles of structural dynamics in the cellular functions of RNAs.

Ganser L, Kelly M, Herschlag D, Al-Hashimi H Nat Rev Mol Cell Biol. 2019; 20(8):474-489.

PMID: 31182864 PMC: 7656661. DOI: 10.1038/s41580-019-0136-0.