Convergence of Biomarkers, Bioinformatics and Nanotechnology for Individualized Cancer Treatment

Overview

Journal Trends Biotechnol

Specialty Biochemistry

Date 2009 May 5

PMID 19409634

Citations 21

Authors

John H Phan

Richard A Moffitt

Todd H Stokes

Jian Liu

Andrew N Young

Shuming Nie

May D Wang

Affiliations

Soon will be listed here.

Abstract

Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.

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