Magnetic Resonance Imaging in Monitoring the Treatment of Multiple Sclerosis: Concerted Action Guidelines

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1991 Aug 1

PMID 1940938

Citations 82

Authors

D H Miller

F Barkhof

I Berry

L Kappos

G Scotti

A J Thompson

Affiliations

Soon will be listed here.

Abstract

Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.

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