Associations of Dietary Long-chain N-3 Polyunsaturated Fatty Acids and Fish with Biomarkers of Inflammation and Endothelial Activation (from the Multi-Ethnic Study of Atherosclerosis [MESA])

Overview

Journal Am J Cardiol

Specialty Cardiology & Vascular Diseases

Date 2009 May 2

PMID 19406265

Citations 63

Authors

Ka He

Kiang Liu

Martha L Daviglus

Nancy Swords Jenny

Elizabeth Mayer-Davis

Rui Jiang

Lyn Steffen

David Siscovick

Michael Tsai

David Herrington

Affiliations

Soon will be listed here.

Abstract

The cardioprotective effects of long-chain n-3 polyunsaturated fatty acids (PUFAs) and fish consumption have been observed. However, data on the specific associations of these dietary factors with inflammation and endothelial activation are sparse. A cross-sectional study was conducted of 5,677 men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, including African Americans, Caucasians, Chinese, and Hispanics aged 45 to 84 years and free of clinical cardiovascular disease. Dietary information was collected using a self-administered food frequency questionnaire. Multivariate linear regression analyses were used to examine relations between the intake of long-chain n-3 PUFAs, nonfried fish, and fried fish and biomarkers of inflammation and endothelial activation. Long-chain n-3 PUFA intake was inversely associated with plasma concentrations of interleukin-6 (p = 0.01) and matrix metalloproteinase-3 (p = 0.03) independent of age, body mass index, physical activity, smoking, alcohol consumption, and dietary variables. Nonfried fish consumption was inversely related to C-reactive protein (p = 0.045) and interleukin-6 (p <0.01), and fried fish consumption was inversely related to soluble intercellular adhesion molecule-1 (p <0.01) but was not associated with other biomarkers after adjustment for potential confounders. In conclusion, the results of this study suggest that the dietary intake of long-chain n-3 PUFAs and fish is inversely associated with concentrations of some biomarkers, reflecting lower levels of inflammation and endothelial activation. These results may partially explain the cardioprotective effects of fish consumption.

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References

Fernandez-Real J, Broch M, Vendrell J, Ricart W . Insulin resistance, inflammation, and serum fatty acid composition. Diabetes Care. 2003; 26(5):1362-8. DOI: 10.2337/diacare.26.5.1362. View

Ray K, Morrow D, Shui A, Rifai N, Cannon C . Relation between soluble intercellular adhesion molecule-1, statin therapy, and long-term risk of clinical cardiovascular events in patients with previous acute coronary syndrome (from PROVE IT-TIMI 22). Am J Cardiol. 2006; 98(7):861-5. DOI: 10.1016/j.amjcard.2006.04.024. View

Calder P . Polyunsaturated fatty acids, inflammation, and immunity. Lipids. 2001; 36(9):1007-24. DOI: 10.1007/s11745-001-0812-7. View

Madsen T, Skou H, Hansen V, Fog L, Christensen J, Toft E . C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol. 2001; 88(10):1139-42. DOI: 10.1016/s0002-9149(01)02049-5. View

Johansen O, Seljeflot I, Hostmark A, Arnesen H . The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease. Arterioscler Thromb Vasc Biol. 1999; 19(7):1681-6. DOI: 10.1161/01.atv.19.7.1681. View

Berstad P, Seljeflot I, Veierod M, Hjerkinn E, Arnesen H, Pedersen J . Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci (Lond). 2003; 105(1):13-20. DOI: 10.1042/CS20020349. View

Cushman M, Cornell E, Howard P, Bovill E, Tracy R . Laboratory methods and quality assurance in the Cardiovascular Health Study. Clin Chem. 1995; 41(2):264-70. View

Bild D, Bluemke D, Burke G, Detrano R, Diez Roux A, Folsom A . Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol. 2002; 156(9):871-81. DOI: 10.1093/aje/kwf113. View

Niu K, Hozawa A, Kuriyama S, Ohmori-Matsuda K, Shimazu T, Nakaya N . Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. Am J Clin Nutr. 2006; 84(1):223-9. DOI: 10.1093/ajcn/84.1.223. View

10.

Seierstad S, Seljeflot I, Johansen O, Hansen R, Haugen M, Rosenlund G . Dietary intake of differently fed salmon; the influence on markers of human atherosclerosis. Eur J Clin Invest. 2005; 35(1):52-9. DOI: 10.1111/j.1365-2362.2005.01443.x. View

11.

Wu T, Leu H, Lin W, Lin C, Lin S, Chen J . Plasma matrix metalloproteinase-3 level is an independent prognostic factor in stable coronary artery disease. Eur J Clin Invest. 2005; 35(9):537-45. DOI: 10.1111/j.1365-2362.2005.01548.x. View

12.

Pischon T, Hankinson S, Hotamisligil G, Rifai N, Willett W, Rimm E . Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003; 108(2):155-60. DOI: 10.1161/01.CIR.0000079224.46084.C2. View

13.

Lopez-Garcia E, Schulze M, Manson J, Meigs J, Albert C, Rifai N . Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr. 2004; 134(7):1806-11. DOI: 10.1093/jn/134.7.1806. View

14.

Bourdillon M, Poston R, Covacho C, Chignier E, Bricca G, McGregor J . ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol. 2000; 20(12):2630-5. DOI: 10.1161/01.atv.20.12.2630. View

15.

Block G, Woods M, Potosky A, Clifford C . Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990; 43(12):1327-35. DOI: 10.1016/0895-4356(90)90099-b. View

16.

Leaf A, Weber P . Cardiovascular effects of n-3 fatty acids. N Engl J Med. 1988; 318(9):549-57. DOI: 10.1056/NEJM198803033180905. View

17.

Hjerkinn E, Seljeflot I, Ellingsen I, Berstad P, Hjermann I, Sandvik L . Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. Am J Clin Nutr. 2005; 81(3):583-9. DOI: 10.1093/ajcn/81.3.583. View

18.

Guallar E, Vant Veer P, Bode P, Aro A, Gomez-Aracena J, Kark J . Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med. 2002; 347(22):1747-54. DOI: 10.1056/NEJMoa020157. View

19.

Zampelas A, Panagiotakos D, Pitsavos C, Das U, Chrysohoou C, Skoumas Y . Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. J Am Coll Cardiol. 2005; 46(1):120-4. DOI: 10.1016/j.jacc.2005.03.048. View

20.

De Caterina R, Zampolli A . n-3 fatty acids: antiatherosclerotic effects. Lipids. 2002; 36 Suppl:S69-78. DOI: 10.1007/s11745-001-0685-9. View