Expression of Tumor-specific Transplantation Antigen in Cell Lines Transformed by Wild-type of TsA Mutant Simian Virus 40

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1977 May 1

PMID 194055

Citations 4

Authors

C Chang

J L Anderson

R G Martin

P T Mora

Affiliations

Soon will be listed here.

Abstract

The simian virus 40-induced tumor-specific surface antigen(s) (TSSA) and tumor-specific transplantation antigen(s) (TSTA)were detected in cells transformed by wild-type or temperature-sensitive mutant simian virus 40 by an antibody-mediated cytolytic assay for TSSA and an immunization test for TSTA. Cells transformed by tsA mutants, which lose their transformed phenotype when grown at nonpermissive temperatures, nonetheless do express TSSA and TSTA as well as T-antigen at both temperatures.

Citing Articles

Correlation between tumour antigens and malignancy in BKV-transformed hamster cells.

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PMID: 2834128 DOI: 10.1007/BF01753579.

Subcellular Localization of simian virus 40 large tumor antigen.

Soule H, Butel J J Virol. 1979; 30(2):523-32.

PMID: 224215 PMC: 353356. DOI: 10.1128/JVI.30.2.523-532.1979.

Relationship between T-antigen and tumor-specific transplantation antigen in simian virus 40-transformed cells.

Chang C, Martin R, Livingston D, LUBORSKY S, Hu C, Mora P J Virol. 1979; 29(1):69-75.

PMID: 219235 PMC: 353074. DOI: 10.1128/JVI.29.1.69-75.1979.

Immunologic selection against simian virus-40 transformed cells: concomitnat loss of viral antigens and early viral gene sequences.

Kuster J, Mora P, Brown M, Khoury G Proc Natl Acad Sci U S A. 1977; 74(11):4796-800.

PMID: 200932 PMC: 432042. DOI: 10.1073/pnas.74.11.4796.

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