Initial Clinical Experience with Helical Tomotherapy for Head and Neck Cancer

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2009 May 1

PMID 19405087

Citations 8

Authors

Allen M Chen

Richard L S Jennelle

Radhika Sreeraman

Claus C Yang

Tianxiao Liu

Srinivasan Vijayakumar

James A Purdy

Affiliations

Soon will be listed here.

Abstract

Background: To report a single-institutional experience with the use of helical tomotherapy (HT)-based intensity-modulated radiotherapy (IMRT) for head and neck cancer.

Methods: Seventy-seven consecutive patients were treated with HT for squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60 to 72 Gy). Megavoltage CT scans were obtained as part of an image-guided registration protocol for patient alignment before each treatment. Concurrent chemotherapy was administered to 48 patients (62%).

Results: The 2-year estimates of overall survival, local-regional control, and disease-free survival were 82%, 77%, and 71%, respectively. Spatial evaluation of local-regional failures revealed that 16 of the 18 patients who progressed in the primary site or neck failed in the high-dose planning target volume (PTV).

Conclusions: HT appears to achieve clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer.

Citing Articles

The Outcome of the First 100 Nasopharyngeal Cancer Patients in Thailand Treated by Helical Tomotherapy.

Chitapanarux I, Nobnop W, Sripan P, Chumachote A, Tharavichitkul E, Chakrabandhu S Radiol Oncol. 2017; 51(3):351-356.

PMID: 28959172 PMC: 5612000. DOI: 10.1515/raon-2017-0017.

Clinical study of nasopharyngeal carcinoma treated by helical tomotherapy in China: 5-year outcomes.

Du L, Zhang X, Ma L, Feng L, Li F, Zhou G Biomed Res Int. 2014; 2014:980767.

PMID: 25114932 PMC: 4119915. DOI: 10.1155/2014/980767.

Helical tomotherapy with simultaneous integrated boost dose painting for the treatment of synchronous primary cancers involving the head and neck.

Chen A, Daly M, Cui J, Wooten H, Farwell D, Purdy J Br J Radiol. 2014; 87(1040):20130697.

PMID: 24884726 PMC: 4112398. DOI: 10.1259/bjr.20130697.

A novel setup approach for helical tomotherapy in head and neck cancer: A case report.

Duma M, Geinitz H, Kampfer S, Kesting M Oncol Lett. 2013; 6(5):1470-1474.

PMID: 24179543 PMC: 3813675. DOI: 10.3892/ol.2013.1558.

Comparison of survival rates between patients treated with conventional radiotherapy and helical tomotherapy for head and neck cancer.

Kong M, Hong S, Choi J, Kim Y Radiat Oncol J. 2013; 31(1):1-11.

PMID: 23620863 PMC: 3633225. DOI: 10.3857/roj.2013.31.1.1.