Fatty Acid Amide Hydrolase (FAAH) Inhibition Enhances Memory Acquisition Through Activation of PPAR-alpha Nuclear Receptors

Overview

Journal Learn Mem

Specialty Neurology

Date 2009 May 1

PMID 19403796

Citations 64

Authors

Carmen Mazzola

Julie Medalie

Maria Scherma

Leigh V Panlilio

Marcello Solinas

Gianluigi Tanda

Filippo Drago

Jean Lud Cadet

Steven R Goldberg

Sevil Yasar

Affiliations

Soon will be listed here.

Abstract

Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB(1)-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for alpha-type peroxisome proliferator-activated nuclear receptors, PPAR-alpha) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by the PPAR-alpha antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-alpha, either directly by administering a PPAR-alpha agonist or indirectly by administering a FAAH inhibitor.

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