Low-molecular-weight Dendrons for DNA Binding and Release by Reduction-triggered Degradation of Multivalent Interactions

Losing the grip: The synthesis of multivalent low-molecular-weight dendrons with lysine branching units coupled to disulfide-linked spermine surface groups is described. It is furthermore demonstrated that the dendrons bind DNA with good affinity (see image), but are also able to release the DNA in a reductive environment.