The Effect of Age on Insulin Sensitivity and Insulin Secretion in First-degree Relatives of Type 1 Diabetic Patients: a Population Analysis

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2009 Apr 30

PMID 19401372

Citations 10

Authors

Xiaosu Ma

Dorothy Becker

Vincent C Arena

Paolo Vicini

Carla Greenbaum

Affiliations

Soon will be listed here.

Abstract

Context: Understanding the role of insulin resistance in type 1 diabetes may lead to new prevention strategies. Estimates of insulin resistance in first-degree relatives of those with type 1 diabetes may be obtained using the minimal model of glucose kinetics incorporating a population approach.

Objective: The objective of the study was to explore parameters contributing to glucose homeostasis in a cross-sectional study of first-degree relatives across a wide age range.

Design: Insulin sensitivity (SI) was assessed using the minimal model of glucose kinetics after an oral glucose tolerance test combined with nonlinear mixed-effects modeling. Beta-cell function was measured from the insulinogenic index at 30 min (IGI(30)). Disposition index (DI) was estimated as the product of SI and IGI(30).

Setting: The study was conducted at an academic center.

Subjects: Subjects included 1241 first-degree relatives (aged 2-75 yr).

Results: SI was found to be negatively correlated with age, whereas IGI(30) increased until young adulthood. The increase IGI(30) was apparently insufficient to compensate for the insulin resistance because DI decreased linearly at the rate of 0.035 (10(-2) min(-1) mmol(-1) liter per year) after young adulthood. Both IGI(30) and DI were significantly lower in those with vs. without autoantibodies, whereas there was no difference between these groups with respect to SI.

Conclusions: Beta-cell function, adjusted for age-related insulin resistance, decreases throughout life in first-degree relatives. This deterioration may be exacerbated in the presence of autoantibodies. Oral glucose tolerance test data combined with a nonlinear mixed-effect modeling population approach may be a useful technique to evaluate SI and secretion in a population.

Citing Articles

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HOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives.

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Association between plant-based or animal-based dietary pattern and plasma glucose during oral glucose tolerance test among Chinese women with gestational diabetes mellitus: a prospective cohort study.

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Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes.

Baidal D, Warnock M, Xu P, Geyer S, Marks J, Moran A J Clin Endocrinol Metab. 2022; 107(8):e3273-e3280.

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Dietary Patterns during Pregnancy Are Associated with the Risk of Gestational Diabetes Mellitus: Evidence from a Chinese Prospective Birth Cohort Study.

Hu J, Oken E, Aris I, Lin P, Ma Y, Ding N Nutrients. 2019; 11(2).

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