Gene-expression Signatures of Atlantic Salmon's Plastic Life Cycle

Overview

Journal Gen Comp Endocrinol

Specialty Endocrinology

Date 2009 Apr 30

PMID 19401203

Citations 18

Authors

Nadia Aubin-Horth

Benjamin H Letcher

Hans A Hofmann

Affiliations

Soon will be listed here.

Abstract

How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators.

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