Cell Mechanics: Dissecting the Physical Responses of Cells to Force

It is now widely appreciated that normal tissue morphology and function rely upon cells' ability to sense and generate forces appropriate to their correct tissue context. Although the effects of forces on cells have been studied for decades, our understanding of how those forces propagate through and act on different cell substructures remains at an early stage. The past decade has seen a resurgence of interest, with a variety of different micromechanical methods in current use that probe cells' dynamic deformation in response to a time-varying force. The ability of researchers to carefully measure the mechanical properties of cells subjected to a variety of pharmacological and genetic interventions, however, currently outstrips our ability to quantitatively interpret the data in many cases. Despite these challenges, the stage is now set for the development of detailed models for cell deformability, motility, and mechanosensing that are rooted at the molecular level.