The Mammalian Family of Sterile 20p-like Protein Kinases

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2009 Apr 29

PMID 19399514

Citations 70

Authors

Eric Delpire

Affiliations

Soon will be listed here.

Abstract

Twenty-eight kinases found in mammalian genomes share similarity to the budding yeast kinase Ste20p. This review article examines the biological function of these mammalian Ste20 kinases. Some of them have conserved the Ste20p function of transducing extracellular signals to mitogen-activated kinases. Others affect ion transport, cell cycle, cytoskeleton organization, and program cell death. A number of molecular details involved in the activation of the kinases are discussed including autophosphorylation, substrate recognition, autoinhibition, dimerization, and substrate binding.

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