Effects of Nanomaterial Physicochemical Properties on in Vivo Toxicity

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2009 Apr 24

PMID 19386275

Citations 164

Authors

Kristin L Aillon

Yumei Xie

Nashwa El-Gendy

Cory J Berkland

M Laird Forrest

Affiliations

Soon will be listed here.

Abstract

It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological interactions. However, most in vivo toxicity concerns focus primarily on pulmonary, oral, and dermal exposures to ultrafine particles. As nanomaterials expand as therapeutics and as diagnostic tools, parenteral administration of engineered nanomaterials should also be recognized as a critical aspect for toxicity consideration. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Here, the physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed.

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