The Mammalian NudC-like Genes: a Family with Functions Other Than Regulating Nuclear Distribution

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2009 Apr 22

PMID 19381437

Citations 14

Authors

Jose Riera

Pedro S Lazo

Affiliations

Soon will be listed here.

Abstract

Nuclear distribution gene C homolog (NudC) is a highly conserved gene. It has been identified in different species from fungi to mammals. The high degree of conservation, in special in the nudC domain, suggests that they are genes with essential functions. Most of the identified genes in the family have been implicated in cell division through the regulation of cytoplasmic dynein. As for mammalian genes, human NUDC has been implicated in the migration and proliferation of tumor cells and has therefore been considered a possible therapeutic target. There is evidence suggesting that mammalian NudC is also implicated in the regulation of the inflammatory response and in thrombopoiesis. The presence of these other functions not related to the interaction with molecular motors agrees with that these genes and their products are larger in size than their microbial orthologous, indicating that they have evolved to convey additional features.

Citing Articles

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Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.

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Identification of Hub Genes Related to Alzheimer's Disease and Major Depressive Disorder.

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NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.

Liu M, Zhang W, Li M, Feng J, Kuang W, Chen X Cell Res. 2021; 31(11):1199-1211.

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