Endogenous Bioactive Lipids and the Regulation of Conventional Outflow Facility

Overview

Journal Expert Rev Ophthalmol

Publisher Informa Healthcare

Specialty Ophthalmology

Date 2011 Sep 28

PMID 19381354

Citations 10

Authors

Zhou Wan

David F Woodward

W Daniel Stamer

Affiliations

Soon will be listed here.

Abstract

Perturbation of paracrine signaling within the human conventional outflow pathway influences tissue homeostasis and outflow function. For example, exogenous introduction of the bioactive lipids, sphingosine-1-phosphate, anandamide or prostaglandin F(2α), to conventional outflow tissues alters the rate of drainage of aqueous humor through the trabecular meshwork, and into Schlemm's canal. This review summarizes recent data that characterizes endogenous bioactive lipids, their receptors and associated signaling partners in the conventional outflow tract. We also discuss the potential of targeting such signaling pathways as a strategy for the development of therapeutics to treat ocular hypertension and glaucoma.

Citing Articles

Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals Follow-up Study.

Kang J, Willett W, Rosner B, Buys E, Wiggs J, Pasquale L JAMA Ophthalmol. 2016; 134(3):294-303.

PMID: 26767881 PMC: 4966649. DOI: 10.1001/jamaophthalmol.2015.5601.

Sphingolipids and ceramides of mouse aqueous humor: Comparative profiles from normotensive and hypertensive DBA/2J mice.

Edwards G, Aribindi K, Guerra Y, Bhattacharya S Biochimie. 2014; 105:99-109.

PMID: 25014247 PMC: 4163522. DOI: 10.1016/j.biochi.2014.06.019.

A comparison of trabecular meshwork sphingolipids and ceramides of ocular normotensive and hypertensive states of DBA/2J mice.

Guerra Y, Aljohani A, Edwards G, Bhattacharya S J Ocul Pharmacol Ther. 2013; 30(2-3):283-90.

PMID: 24320088 PMC: 3991980. DOI: 10.1089/jop.2013.0168.

Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma.

Rao P J Ocul Pharmacol Ther. 2013; 30(2-3):181-90.

PMID: 24283588 PMC: 3991961. DOI: 10.1089/jop.2013.0194.

Sphingolipids and ceramides in human aqueous humor.

Aljohani A, Munguba G, Guerra Y, Lee R, Bhattacharya S Mol Vis. 2013; 19:1966-84.

PMID: 24068864 PMC: 3782370.

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