Puma Strikes Bax

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2009 Apr 22

PMID 19380876

Citations 17

Authors

Anthony Letai

Affiliations

Soon will be listed here.

Abstract

The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol. 185:279-290) provide evidence that the p53 up-regulated modulator of apoptosis (Puma) protein can directly activate Bax.

Citing Articles

Cancer and Apoptosis.

Chaudhry G, Md Akim A, Sung Y, Tengku Muhammad T Methods Mol Biol. 2022; 2543:191-210.

PMID: 36087269 DOI: 10.1007/978-1-0716-2553-8_16.

Expression and inhibitory effects of p53-upregulated modulator of apoptosis in gallbladder carcinoma.

Liu Z, Yan C, Xiao Y, Zhang W, Wang L, Li Q Oncol Lett. 2021; 21(3):234.

PMID: 33613723 PMC: 7856684. DOI: 10.3892/ol.2021.12495.

Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism.

Zhang L, Yan B, Meng S, Zhou L, Xu Y, Du W Front Pharmacol. 2020; 11:1317.

PMID: 32982737 PMC: 7490558. DOI: 10.3389/fphar.2020.01317.

Immunotoxicity of titanium dioxide nanoparticles via simultaneous induction of apoptosis and multiple toll-like receptors signaling through ROS-dependent SAPK/JNK and p38 MAPK activation.

Dhupal M, Oh J, Tripathy D, Kim S, Koh S, Park K Int J Nanomedicine. 2018; 13:6735-6750.

PMID: 30425486 PMC: 6204851. DOI: 10.2147/IJN.S176087.

Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells.

Tu S, Zhang X, Wan H, Xia Y, Liu Z, Yang X Oncol Lett. 2018; 15(4):5473-5480.

PMID: 29552188 PMC: 5840730. DOI: 10.3892/ol.2018.8036.

References

Wei M, Zong W, Cheng E, LINDSTEN T, Panoutsakopoulou V, Ross A . Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 2001; 292(5517):727-30. PMC: 3049805. DOI: 10.1126/science.1059108. View

Lovell J, Billen L, Bindner S, Shamas-Din A, Fradin C, Leber B . Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell. 2008; 135(6):1074-84. DOI: 10.1016/j.cell.2008.11.010. View

Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P . p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003; 11(3):577-90. DOI: 10.1016/s1097-2765(03)00050-9. View

Willis S, Fletcher J, Kaufmann T, van Delft M, Chen L, Czabotar P . Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 2007; 315(5813):856-9. DOI: 10.1126/science.1133289. View

Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A . BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell. 2007; 12(2):171-85. DOI: 10.1016/j.ccr.2007.07.001. View

Kim H, Rafiuddin-Shah M, Tu H, Jeffers J, Zambetti G, Hsieh J . Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol. 2006; 8(12):1348-58. DOI: 10.1038/ncb1499. View

Kuwana T, Mackey M, Perkins G, Ellisman M, Latterich M, Schneiter R . Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell. 2002; 111(3):331-42. DOI: 10.1016/s0092-8674(02)01036-x. View

Kuwana T, Bouchier-Hayes L, Chipuk J, Bonzon C, Sullivan B, Green D . BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005; 17(4):525-35. DOI: 10.1016/j.molcel.2005.02.003. View

Chipuk J, Kuwana T, Bouchier-Hayes L, Droin N, Newmeyer D, Schuler M . Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004; 303(5660):1010-4. DOI: 10.1126/science.1092734. View

10.

Jeffers J, Parganas E, Lee Y, Yang C, Wang J, Brennan J . Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003; 4(4):321-8. DOI: 10.1016/s1535-6108(03)00244-7. View

11.

Cartron P, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P . The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol Cell. 2004; 16(5):807-18. DOI: 10.1016/j.molcel.2004.10.028. View

12.

Gavathiotis E, Suzuki M, Davis M, Pitter K, Bird G, Katz S . BAX activation is initiated at a novel interaction site. Nature. 2008; 455(7216):1076-81. PMC: 2597110. DOI: 10.1038/nature07396. View

13.

Certo M, Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong S . Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006; 9(5):351-65. DOI: 10.1016/j.ccr.2006.03.027. View

14.

LINDSTEN T, Ross A, King A, Zong W, Rathmell J, Shiels H . The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2001; 6(6):1389-99. PMC: 3057227. DOI: 10.1016/s1097-2765(00)00136-2. View

15.

Wei M, LINDSTEN T, Mootha V, Weiler S, Gross A, Ashiya M . tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 2000; 14(16):2060-71. PMC: 316859. View

16.

Nakano K, Vousden K . PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001; 7(3):683-94. DOI: 10.1016/s1097-2765(01)00214-3. View

17.

Villunger A, Michalak E, Coultas L, Mullauer F, Bock G, Ausserlechner M . p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science. 2003; 302(5647):1036-8. DOI: 10.1126/science.1090072. View

18.

Pagliari L, Kuwana T, Bonzon C, Newmeyer D, Tu S, Beere H . The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci U S A. 2005; 102(50):17975-80. PMC: 1312392. DOI: 10.1073/pnas.0506712102. View

19.

Gallenne T, Gautier F, Oliver L, Hervouet E, Noel B, Hickman J . Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol. 2009; 185(2):279-90. PMC: 2700382. DOI: 10.1083/jcb.200809153. View