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Targeting DNA Topoisomerase II in Cancer Chemotherapy

Overview
Journal Nat Rev Cancer
Specialty Oncology
Date 2009 Apr 21
PMID 19377506
Citations 747
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Abstract

Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy.

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References
1.
Liu C, Pouliot J, Nash H . The role of TDP1 from budding yeast in the repair of DNA damage. DNA Repair (Amst). 2004; 3(6):593-601. DOI: 10.1016/j.dnarep.2004.03.030. View

2.
Dona F, Prosperi E, Savio M, Coppa T, Scovassi A, Mondello C . Loss of histone H2AX increases sensitivity of immortalized mouse fibroblasts to the topoisomerase II inhibitor etoposide. Int J Oncol. 2008; 33(3):613-21. View

3.
Theard D, Coisy M, Ducommun B, Concannon P, Darbon J . Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR. Biochem Biophys Res Commun. 2001; 289(5):1199-204. DOI: 10.1006/bbrc.2001.6095. View

4.
Fortune J, Osheroff N . Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog Nucleic Acid Res Mol Biol. 2000; 64:221-53. DOI: 10.1016/s0079-6603(00)64006-0. View

5.
Mistry A, Felix C, Whitmarsh R, Mason A, Reiter A, Cassinat B . DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med. 2005; 352(15):1529-38. DOI: 10.1056/NEJMoa042715. View