Outcome of Surgical Management of Bisphosphonate-related Osteonecrosis of the Jaws: Review of 33 Surgical Cases

Overview

Journal J Oral Maxillofac Surg

Specialties Dentistry
General Surgery

Date 2009 Apr 21

PMID 19375001

Citations 36

Authors

David C Stanton

Edward Balasanian

Affiliations

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Abstract

Purpose: We describe our experience with surgical management of bisphosphonate-related osteonecrosis of the jaws (BRONJ).

Materials And Methods: The data included 33 BRONJ cases treated surgically by a single surgeon at the Hospital of the University of Pennsylvania.

Results: Of the 30 debridement patients, 25 (including 1 sequestrectomy patient who required formal debridement) healed completely. Of the 30 patients who underwent surgical debridement, 18 healed following this initial treatment and remained healed. Of the 4 patients requiring sequestrectomy, 3 healed after the initial treatment. Thus, 28 of 33 patients healed completely with complete mucosal coverage and elimination of pain. Four patients developed occurrence of BRONJ at a separate site. All 4 patients were treated with our surgery protocol and remain healed. Thus, 32 of 37 BRONJ occurrences have healed with our surgical debridement protocol or sequestrectomy. The follow-up range was 1 to 40 months (average 10.7).

Conclusions: The results of our case series have shown that surgical debridement can be successful in treating BRONJ.

Citing Articles

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PMID: 38575664 PMC: 10994931. DOI: 10.1038/s41598-024-57635-5.

Associated systemic diseases and etiologies of medication-related osteonecrosis of the jaw: a retrospective study of 265 surgical cases.

Chang H, Kim M, Ahn K Maxillofac Plast Reconstr Surg. 2023; 45(1):12.

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Reporting Criteria for Clinical Trials on Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review and Recommendations.

Gaudet C, Odet S, Meyer C, Chatelain B, Weber E, Parmentier A Cells. 2022; 11(24).

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Therapeutic Effect of Benidipine on Medication-Related Osteonecrosis of the Jaw.

Matsunaka K, Imai M, Sanda K, Yasunami N, Furuhashi A, Atsuta I Pharmaceuticals (Basel). 2022; 15(8).

PMID: 36015167 PMC: 9412249. DOI: 10.3390/ph15081020.

Interventions for managing medication-related osteonecrosis of the jaw.

Beth-Tasdogan N, Mayer B, Hussein H, Zolk O, Peter J Cochrane Database Syst Rev. 2022; 7:CD012432.

PMID: 35866376 PMC: 9309005. DOI: 10.1002/14651858.CD012432.pub3.